DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and Nuak2

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_001007618.1	Gene:	Nuak2 / 289419	RGDID:	1359167	Length:	630	Species:	Rattus norvegicus

Alignment Length:	769	Identity:	246/769 - (31%)
Similarity:	348/769 - (45%)	Gaps:	197/769 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 APNGAAGGAEAAAPTGLDATGNSLAHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRFDIIK 74
            ||:.:|...|:|.|    .....:..|..:.:.|.            ||.::|:..||.|::.::
  Rat    13 APSASALATESARP----LADRLIKSPKPLMKKQA------------VKRHHHKHNLRHRYEFLE 61

  Fly    75 KLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFEN 139
            .||:||||||:.. .:.:|:.||||:|:|.||:.|.||:.||||::||||::||:||.|:|||||
  Rat    62 TLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVFEN 125

  Fly   140 REKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEK 204
            ..|:|:|||:|:.|:||||:|||..|.|.:||..|||:.:|::|||::.|.||||||||||||..
  Rat   126 SSKIVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDAS 190

  Fly   205 GNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFD 269
            ||.|||||||||::...:.|.||||||||||||||.|.||.|||||.||||||||.||:|:||||
  Rat   191 GNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPFD 255

  Fly   270 GSNFKRLVKQISQGDYYEPRKPSRASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDLAE 334
            |.:.|.||||||.|.|.||.|||.|..|||.:|.|.|.:||::|.:.||||||       ...:.
  Rat   256 GQDHKTLVKQISSGAYREPCKPSDACGLIRWLLMVNPIRRATLEDVASHWWVN-------WGYST 313

  Fly   335 DLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAE 399
            .:..|..:|               :...||.:...|:.|....|..|            |..|..
  Rat   314 RIGEQEALR---------------EGGHPSGDSGRASMADWLRRSSR------------PLLENG 351

  Fly   400 RRILDM----VAAGGEAALMPSPTRTITPAQSPVQTKRK---LQPTVSTENAAGTTAKKKEKPAN 457
            .::...    |..||...  |...|     |..::..||   :..|:..:.|..|::    :|..
  Rat   352 AKVCSFFKQHVPGGGSTG--PGLER-----QHSLKKSRKENDMAQTLQNDPAEDTSS----RPGK 405

  Fly   458 SSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATT 522
            :|..:.| |....:|.|:..|.|....|...::|.|.:
  Rat   406 NSLKLPK-GILKKKASPSSGEVQEGPQELRPVSNTPGQ--------------------------- 442

  Fly   523 PAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSA 587
            |.||.|.      .|.:|                ::||
  Rat   443 PVPAIPL------LPRKG----------------ILKK--------------------------- 458

  Fly   588 VAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGVSV--GS 650
                      |.|.||.............:|:..:.|....|:....|:...:|...|:..  |.
  Rat   459 ----------SRQRESGYYSSPEPSESGELLDAGDVFVSGDPMEQKSPQASGRLHRKGILKLNGK 513

  Fly   651 FKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEGSDSKNSV- 714
            |.:         .|.||..|....:.:|:|:....|:     ::.|...|...|:..|:|.:.:
  Rat   514 FSR---------TALEGTAPSTFGSLDQLASPHPTAR-----ASRPSGAVSEDSILSSESFDQLD 564

  Fly   715 -----------ASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIGVS 757
                       ..:|:|..||        |.|..:|..|...|     |::|.|
  Rat   565 LPERLPETPLRGCVSVDNLRR--------LEQPPSEGLKRWWQ-----ESLGDS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	154/252 (61%)
Nuak2	NP_001007618.1	PKc_like	53..307	CDD:304357	156/254 (61%)
		S_TKc	57..307	CDD:214567	153/250 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..504		39/240 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..566		10/49 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349133
Domainoid	1	1.000	331	1.000	Domainoid score	I1111
eggNOG	1	0.900	-	-		E1_KOG0611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002307
OrthoInspector	1	1.000	-	-		otm45662
orthoMCL	1	0.900	-	-		OOG6_106932
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2001
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.640