Protein Alignment Nuak and Smok2a

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_038769.1
• Gene: Smok2a / 27263
• MGIID: 1351487
• Length: 504
• Species: Mus musculus
• Alignment Length: 524
• Identity: 139/524 - (26%)
• Similarity: 234/524 - (44%)
• Gaps: 105/524 - (20%)

  Fly    64 KKLRQR------------FDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKK----CKIEAEADL 112
            :|||.:            ::::..:|.|...||:|..::.||..||:|.|.|    ||
Mouse    10 EKLRSKPPFSEMENFHAQYEMLGTIGHGGSTKVKLARHRLTGTHVAVKMIPKREYWCK------- 67

  Fly   113 VRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQV 177
             .:..|.:::....|||||.:.:|.|.::|:.|:||...|..||.::.....|.|:|||.:|:|:
Mouse    68 -PLMSEAELLMMADHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQL 131

  Fly   178 ATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGT 242
            .:|:.|||...|.|||||.:||::::.|..||.||||.......:.|..|||:..:::||::...
Mouse   132 LSAINYCHNQGIVHRDLKPDNIMVEKDGRVKIIDFGLGIQVKPGQKLNLFCGTYPFSAPEVLLSR 196

  Fly   243 PYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEP-RKPSRASTLIRDMLTVCP 306
            ||.||::|.|:|||:||.:|.|.:|||.::.::|.|||..|.|..| |...:...||..::|..|
Mouse   197 PYDGPKIDVWTLGVVLYFMVTGKIPFDAASIEKLRKQIVAGKYSVPCRLSVKLHHLITLLMTDNP 261

  Fly   307 RKRASIEQICSHWWVNENDNVSCLDLAEDLANQTPVRLDVLLSLTPATITA------------DQ 359
            ..|.::.::..|.||.:...|    ..:....|.|::.|      ||.:.|            |.
Mouse   262 ELRPTVAEVMMHPWVTKGSGV----FPDPCEEQIPLKPD------PAIVKAMGHIGFQAQDIEDS 316

  Fly   360 LVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITP 424
            |.........|:.....:::.:               |.:|.|.   |.....::.|.|:...||
Mouse   317 LRQRKFNETMASYCLLKKQILK---------------ECDRPIR---AQPMNPSVTPFPSLVDTP 363

  Fly   425 AQSPVQTKRKLQPTVSTENA-------AGTTAKKKEKPANSSFVISKDGAPLTEAPP-------- 474
            .......:|:.:||....:|       ..:|:||:::..:...|:|:   |:...|.
Mouse   364 TFHLGLRRRETEPTSLRLSANRQMSVCGRSTSKKRDRSFSWPGVLSR---PINITPTMDQTHTCT 425

  Fly   475 ----------TIIEPQAT--LMEAETIANIPEEVPVPS---------YSQKDMQAVGDICDLLMG 518
                      .||.|.::  ..|..|.|: .|:.||.|         ::.|...|:..:|..:..
Mouse   426 RSVPCINSNFCIIHPNSSDESTEGHTSAS-AEDKPVRSRGWPRGIKGWTSKIGNAMRKLCCCIPS 489

  Fly   519 TATT 522
            ..|:
Mouse   490 NETS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	91/269 (34%)
Smok2a	NP_038769.1	STKc_AMPK-like	27..275	CDD:270905	91/255 (36%)
		UBA_MARK_Par1	295..334	CDD:270522	7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	376..403		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..469		7/26 (27%)