Protein Alignment Nuak1 and Hunk

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_056570.1
• Gene: Hunk / 26559
• MGIID: 1347352
• Length: 714
• Species: Mus musculus
• Alignment Length: 960
• Identity: 222/960 - (23%)
• Similarity: 353/960 - (36%)
• Gaps: 309/960 - (32%)

  Fly     2 VISKPDGTAPNGAAGGAEAAAPTGLDATGNSL-AHPSGIPQDQIDNIMSGIANTGNVKMNNHRKK 65
            ::.:|  .|| |..||||..........|:.| |..||:.::::.:.             .|.|:
Mouse     9 LLGEP--AAP-GGDGGAEDTTRPAAACEGSFLPAWVSGVSRERLRDF-------------QHHKR 57

  Fly    66 LRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVR-IRREVQIMSSVHHPN 129
            :.......:|||:|::.||:.|::..||::||||.|.|.:.:.:..:.: :|||.||...:.|||
Mouse    58 VGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPN 122

  Fly   130 IIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDL 194
            |..:.::.|......||||...||.|...:.|:|.|.|.||||..||:.:||.:.|:..:.||||
Mouse   123 ITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDL 187

  Fly   195 KLENILLDEKGNAKIADFGLSNV-----FDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSL 254
            |:||:||||..|.|:.||||||.     :.|.  ..|.||||.||:||::....| ||::|.||:
Mouse   188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDP--FSTQCGSPAYAAPELLARKKY-GPKIDVWSI 249

  Fly   255 GVLLYTLVYGSMPFDGSNFK-RLVKQISQGDYYEPRKPSRAST----LIRDMLTVCPRKRASIEQ 314
            ||.:|.::.|::||....|. |.:.|........| .|::.||    .:|.:|...|.||.:|:|
Mouse   250 GVNMYAMLTGTLPFTVEPFSLRALYQKMVDKAMNP-LPTQLSTGAVNFLRSLLEPDPVKRPNIQQ 313

  Fly   315 ICSHWWVNEN--DNVSC------------------LDLAEDLANQTPVRLDVLLSLTPATITADQ 359
            ..::.|:|||  ..|.|                  |.:.|.|..:....::.:||.....|.|..
Mouse   314 ALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIY 378

  Fly   360 LVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITP 424
            .::             |:::.|..|             .:..|.|.:....:...:.....|..|
Mouse   379 FLL-------------NKKLERYLS-------------GKSDIQDSICYKTQLYQIEKCRATKEP 417

  Fly   425 AQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETI 489
            .::.:.|.     |...|..|....|.||:.....|               :..|.:..::..
Mouse   418 YEASLDTW-----TRDFEFHAVQDKKPKEQEKRGDF---------------LHRPFSKKLDKN-- 460

  Fly   490 ANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVAR-QPTRGKLDAVVETPEEKD 553
                    :||:.|                        |:|:.:.: |.|:..|       :::.
Mouse   461 --------LPSHKQ------------------------PSPSLITQLQSTKALL-------KDRK 486

  Fly   554 ATKVIKKFVNK---------HKTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNKFN 609
            |:|  ..|.:|         .||:| .|.: .|:|....||    |||
Mouse   487 ASK--SGFPDKDSFVCRNLFRKTSD-SNCV-ASSSMEFIPV----PPP----------------- 526

  Fly   610 AERRKSRILETAEKFQPPPPVAA-APPEKPKKLSIPGVSVGSFKKEFEKKATNPPAAEGPTPGEL 673
               |..||::..|..||.|..|: .|.|:|..|.
Mouse   527 ---RTPRIVKKLEPHQPGPGSASILPKEEPLLLD------------------------------- 557

  Fly   674 RAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQN 738
                                       :.:|.|..|.::.:..:|.....|.:.:.::|   |:.
Mouse   558 ---------------------------MVRSFESVDREDHIELLSPSHHYRILSSPVSL---ARR 592

  Fly   739 ESSKEVDQLCAQTETIGVSEPATQQERERKLKNARAIIGNAIQPVIRRPTPFYGIGNGFGNGMGG 803
            .||                        ||.|  ::.::..:..|:   .||.:..
Mouse   593 NSS------------------------ERTL--SQGLLSGSTSPL---QTPLHST---------- 618

  Fly   804 AVGASGATVNNAPKRAQSGSSFMGYSGATSPGTAATSPPISGPQTAPPVLISPNALAVAKQTIQQ 868
            .|..:....|:.||.          .|..||      ||:.......| |.|||.       ::.
Mouse   619 LVSFAHEEKNSPPKE----------EGVCSP------PPVPSNGLLQP-LGSPNC-------VKS 659

  Fly   869 RIFGGGLPSPN-NQPANRRPATWQPQASYS---TASIFQPPQSQSSPFKM 914
            |   |..|... .|...:|..:.||.:..|   :.|..||....|..|.|
Mouse   660 R---GRFPMMGIGQMLRKRHQSLQPSSERSLDASMSPLQPTAPSSLSFDM 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	100/263 (38%)
Hunk	NP_056570.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		8/21 (38%)
		STKc_HUNK	58..320	CDD:270972	100/265 (38%)
		S_TKc	61..320	CDD:214567	100/262 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..658		13/57 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..714		10/33 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930