DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and fin1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_593305.1	Gene:	fin1 / 2542237	PomBaseID:	SPAC19E9.02	Length:	722	Species:	Schizosaccharomyces pombe

Alignment Length:	837	Identity:	185/837 - (22%)
Similarity:	318/837 - (37%)	Gaps:	251/837 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 QRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIH 132
            :::.|::.:|.|::|::......:.|..:|.|.|....|..: :...|..||.|:.::.||||:.
pombe     2 EKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQ-EKQYIADEVNILRNLKHPNIVQ 65

  Fly   133 IYEVFENREKMV--LVMEFAAGGELYD----YLSERKVLTEEEARRIFRQVATAVYYCH------ 185
            ......||...|  |.||:...|:|.:    |..|:|..||:|..:.|.|:..|:|.||
pombe    66 YCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAP 130

  Fly   186 -------------KHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLL-GTFCGSPLYASP 236
                         |..:.|||:|..||.|||..:.|:.|||||.:.|:.|:. .::.|:|.|.||
pombe   131 ACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSP 195

  Fly   237 EIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPSRASTLIRDM 301
            ||:..:||.. :.|.|:||.:::.:...:.||:|.::..|.:.|.||:
pombe   196 EIIRSSPYSA-KSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGN----------------- 242

  Fly   302 LTVCPRKRASIEQICSHWWVNENDNV-----SCLDLAEDLANQT------PVRLDVLLSLTPATI 355
                          .|.|..:.:|:|     .||::..||...|      |:..|:...|....:
pombe   243 --------------LSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIRSKLESERV 293

  Fly   356 TAD---------QLVV-----------------PSAEGAAAAKAAANERVPRSHSVGSIRDMGPP 394
            ..:         |:::                 ...|...|::.|..|.:.|
pombe   294 VLEQSDLLHKKHQMLIQLENDLQFREQRLSARESELENVIASRLAQREEILR------------- 345

  Fly   395 NTEAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSS 459
             .|.|:::.||.|            |.....|:.|.:.:|::.|...::        .|:|.:|:
pombe   346 -RELEKQLRDMDA------------RYQRHMQTVVNSMQKMRVTSPVDH--------NEQPESST 389

  Fly   460 ---FV---ISKDGAPLTEAPPT-IIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLM 517
               ||   |....:||...|.. |.:|..||             ..|.:
pombe   390 AEMFVDCTIEASQSPLLHIPKLGISKPLQTL-------------SCPGF---------------- 425

  Fly   518 GTATTPAPAPPAPTPVARQPT-------------------RGKLDAVVETPEEKDA--TKVIKKF 561
             |.||       ..|:.::||                   |....::..||.:||.  |.:.:|.
pombe   426 -TLTT-------QQPILKRPTLRKELSSRALHTTATLMKYRANASSLRTTPIDKDGQITSLQQKN 482

  Fly   562 VNKHKTADLVNAINESA--SKAAAPVSAV--------APPPFVRKCSLQ-DESTLNKFNAER--R 613
            ...::.||.:|.:..::  .|..:|....        .|...|.|.|:: ||:.::..:.|.  .
pombe   483 GTSNQVADCMNKLLHTSLDGKKLSPSELCNKFSDGEGLPNRKVSKLSVESDETAVSASSGESVPT 547

  Fly   614 KSRILETAEK--FQPPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKKATN-------PPAAEGPT 669
            .|.:.:|..|  |..||...:...||.:||:|....|..     ..||:.       |..|   :
pombe   548 DSTLTDTKSKSVFVHPPSPQSLYVEKLEKLNIRSDEVSK-----PSKASKTLHGYALPSLA---S 604

  Fly   670 PGELRAQEQVAAAAAAAQEAETLST---PPP----SPVVAQSLEGSDSK--NSVASISLDEARRS 725
            |.::.|:|::|.........:|:..   |..    :|...|.|||....  ..:..:..::.|||
pombe   605 PYDVHAEEKIARENEMDGNFKTMKINQHPDEYVLRTPKKIQLLEGQKRSPVKQLGRLGYNKLRRS 669

  Fly   726 -MENSIALLLQAQNESSKEVDQLCAQTETIGVSEPATQQERE--------RKLKNAR 773
             |:|:...|.:|.:.|    :....|:.|:    |.:.::.|        ||:.:||
pombe   670 AMDNAGLELRKAASTS----NYTSLQSRTL----PGSWRDDEEEIPRPFLRKMLDAR 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	77/278 (28%)
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	85/310 (27%)
fin1	NP_593305.1	S_TKc	4..281	CDD:214567	85/309 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910