Protein Alignment Nuak and Smok2b

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_001161385.1
• Gene: Smok2b / 236574
• MGIID: 3037705
• Length: 484
• Species: Mus musculus
• Alignment Length: 477
• Identity: 141/477 - (29%)
• Similarity: 227/477 - (47%)
• Gaps: 86/477 - (18%)

  Fly    69 RFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHI 133
            ::.:::.:|.|...||.|..::.||..||:|.|:|    :|.....:..||:::....|||||.:
Mouse     7 QYVMLETIGHGGCSKVMLARHRLTGSHVAVKMIRK----SECWCNPVMSEVELLMMADHPNIISL 67

  Fly   134 YEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLEN 198
            .:|.|.::|:.|:||...|..||.::.....|.|:|||.:|:|:.:|:.|||...|.|||||.:|
Mouse    68 LQVIETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQLLSAMNYCHNQGIVHRDLKPDN 132

  Fly   199 ILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVY 263
            |::::.|..||.||||.......:.|..|||:..:::||::...||.||::|.|:|||:||.:|.
Mouse   133 IMVEKDGKVKIIDFGLGTQVKPGQKLNLFCGTYPFSAPEVLLSRPYDGPKIDVWTLGVVLYFMVT 197

  Fly   264 GSMPFDGSNFKRLVKQISQGDYYEPRKPSRASTLIRD----MLTVCPRKRASIEQICSHWWVNEN 324
            |.:|||.::.::||:||..|.|:   .|||.|..:||    ::|..|:.|.::.::..|.||.|.
Mouse   198 GKVPFDAASIQKLVRQILAGKYF---VPSRLSVELRDLISLLMTANPKLRPTVAEVMVHPWVTEG 259

  Fly   325 DNVSCLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIR 389
            ..|    ..:....|.|      |...||.:        .|.|....:|...|        .|:|
Mouse   260 SGV----FPDPCEEQMP------LKPNPAIV--------KAMGYIGFQAQDIE--------DSLR 298

  Fly   390 DMGPPNTEAERRIL-DMVAAGGEAALMPSPTR-TITPAQSPVQT--------KRKLQPTVSTENA 444
            ......|.|...:| ..:....:..:...|.. ::||..|.|.|        :|:.:||....:|
Mouse   299 QRKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPFPSLVDTSTFHLGLRRRETEPTSLRLSA 363

  Fly   445 -------AGTTAKKKEK----PANSSFVISKDGAPL------------TEAPPTI------IEPQ 480
                   ..:|:||:::    |       |..|.||            |.:.|.|      |:|.
Mouse   364 NRQMSVCGRSTSKKRDRRFSWP-------SVSGRPLHTTHTMDHTHTRTRSVPCIYSMFCTIQPN 421

  Fly   481 AT--LMEAETIANIPEEVPVPS 500
            ::  ..|..|.|: .|:.||.|
Mouse   422 SSDDSTEGHTSAS-AEDKPVRS 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	93/255 (36%)
Smok2b	NP_001161385.1	STKc_AMPK-like	7..255	CDD:270905	93/254 (37%)
		UBA_MARK_Par1	275..314	CDD:270522	11/54 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..400		11/50 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..450		7/22 (32%)