Protein Alignment Nuak and Snrk

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_598502.2
• Gene: Snrk / 20623
• MGIID: 108104
• Length: 748
• Species: Mus musculus
• Alignment Length: 952
• Identity: 225/952 - (23%)
• Similarity: 340/952 - (35%)
• Gaps: 257/952 - (26%)

  Fly    65 KLRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPN 129
            |:...:|:.|.||:|.:..|:|..:..||::||:|.|.|.|::..| ...:.:||:.|..|.|||
Mouse    11 KIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLA-TGHLFQEVRCMKLVQHPN 74

  Fly   130 IIHIYEVFENREKMVLVMEFAAGGELYDYLSERKV-LTEEEARRIFRQVATAVYYCHKHKICHRD 193
            |:.:|||.:.:.|:.|::|...||:::||:.:.:. |.|:.|::.|.|:..|:.||||..:.|||
Mouse    75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRD 139

  Fly   194 LKLENILLDEK-GNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVL 257
            ||.||::..|| |..|:.|||.||.|...:.|.|.|||..|::|||:.|..|..|.||.|||||:
Mouse   140 LKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVI 204

  Fly   258 LYTLVYGSMPFDGSNFKRLVKQISQGDY-YEPRKPSRASTLIRDMLTVCPRKRASIEQICSHWWV 321
            |:.||.|..||..:|....:..|....| ..||..:....||..||...|::|||:|:|.||.|:
Mouse   205 LFMLVCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWL 269

  Fly   322 NENDN----------VSCLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAAN 376
            ...|.          ||..:|:|:..|....|: ||..:.......:.|.........|......
Mouse   270 QGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRM-VLGDIADRDAIVEALETNRYNHITATYFLLA 333

  Fly   377 ERVPRSHSVGSI--RDMGPPNTEAERR-----ILDMVAAGGEAALMPSPTRTITPAQSPVQTKRK 434
            ||:.|......|  |...|.|.:|:.|     .:| |....|..|..:|....|..|||.   |.
Mouse   334 ERILREKQEKEIQTRSASPSNIKAQFRQSWPTKID-VPQDLEDDLTATPLSHATVPQSPA---RA 394

  Fly   435 LQPTVSTENAAG--TTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVP 497
            ....::...:.|  ..|||.|.|..:       |..|:..||..::|.|:..:........||
Mouse   395 GDNVLNGHRSKGLCDPAKKDELPELA-------GPALSTVPPASMKPAASGRKCLFRVEEDEE-- 450

  Fly   498 VPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVARQPTRGKLDAVVETPEEKDATKVIKKFV 562
                                                             |..|:|....:..:.|
Mouse   451 -------------------------------------------------EDEEDKKPVSLSTQVV 466

  Fly   563 NKHKTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPP 627
            .:.|.    :..|...|:.:|||                   ||:...|.......:..|..
Mouse   467 LRRKP----SVTNRLTSRKSAPV-------------------LNQIFEEGESDDEFDMDENL--- 505

  Fly   628 PPVAAAPPEKPKKLSIPGVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAAQEAETL 692
                   |.|..:|.:...|.|:..|.:.::     .::|
Mouse   506 -------PPKLSRLKMNIASPGTVHKRYHRR-----KSQG------------------------- 533

  Fly   693 STPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIGVS 757
                         .||...:|..|....|:||.::.............|.|             .
Mouse   534 -------------RGSSCSSSETSDDDSESRRRLDKDSGFAYSWHRRDSSE-------------G 572

  Fly   758 EPATQQERERKLKNARAIIGNAIQPVIRRPTPFYGIGNGFGNGMGGAVGASGATVNNA-PKRAQS 821
            .|.::                                   |:|.|.:..:||..|:.| |....:
Mouse   573 PPGSE-----------------------------------GDGGGQSKPSSGGGVDKASPGEQGT 602

  Fly   822 GSSFMGYSGATSPGTAATSPPISGPQTAPPVLISPNALAVAKQTIQ-----QRIFGGGLPSPNNQ 881
            |....|.||.|..|||.:|...:||.::.|...|.:|.....:.:|     ....|..|..
Mouse   603 GGGSQGGSGGTPSGTAGSSRRCAGPDSSSPSPASASAAPRGAELVQSLKLVSLCLGSQLHG---- 663

  Fly   882 PANRRPATWQPQASYSTASIFQPPQSQSSPFKMLQQQYQQRCQEDQKQSCPFTPPPSP------- 939
                        |.|    |..|.::..|..|:.::...:.|..        .|.|||
Mouse   664 ------------AKY----ILDPQKALFSSVKVQEKSTWKMCIS--------APGPSPSADLDPV 704

  Fly   940 ------QNAASHAYAAQANSNNYGGNSNSGASGGSSSNSRCN 975
                  .||.......:..|.|...:...|....||..|.|:
Mouse   705 RTKKLRNNALQLPLCEKTISVNIQRSRKEGLLCASSPASCCH 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	103/255 (40%)
Snrk	NP_598502.2	STKc_SNRK	12..269	CDD:270976	103/257 (40%)
		UBA_SNRK	288..335	CDD:270524	8/47 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..415		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..640		40/249 (16%)