Protein Alignment Nuak1 and unc-82

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: NP_001255294.1
• Gene: unc-82 / 177514
• WormBaseID: WBGene00006814
• Length: 1793
• Species: Caenorhabditis elegans
• Alignment Length: 1950
• Identity: 466/1950 - (23%)
• Similarity: 704/1950 - (36%)
• Gaps: 630/1950 - (32%)

  Fly     1 MVISKPDGTAPNGAAGGAEA---------AAPTGLDATG--NSL---AHPSGIPQDQIDNIMSGI 51
            ::|....|..|.|.:|....         ..|.|.:..|  ||.   .||           |||.
 Worm   231 VIIDPTGGRMPVGNSGSRSGRLARISQSNIRPFGSNGGGATNSYGPGTHP-----------MSGA 284

  Fly    52 ANTGNVKMNNHRKKLRQRFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIR 116
            ......|...|      ||:|.||||.||||||.|..:.:..:|||:|.|||..||::|||||||
 Worm   285 EPCSPTKKEKH------RFEITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIR 343

  Fly   117 REVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAV 181
            ||::|||:::|||||.|||||||::|::||||:::|||||||:|....|.|.||||||||:.:||
 Worm   344 REIRIMSALNHPNIIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAV 408

  Fly   182 YYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQG 246
            .|||||::.||||||||||||:..|||||||||||.|.|:.||.|||||||||||||:.||||:|
 Worm   409 LYCHKHRVAHRDLKLENILLDQNNNAKIADFGLSNYFADKNLLTTFCGSPLYASPEIINGTPYKG 473

  Fly   247 PEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPSRASTLIRDMLTVCPRKRAS 311
            |||||||||:||||||||||||||.:|.|:|:||.:|.|:||..||.||.|||:||.|.|.:||:
 Worm   474 PEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFEPETPSTASMLIRNMLRVNPERRAT 538

  Fly   312 IEQICSHWWVNENDNVSCL-DLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAA 375
            |..|.||||:|..:|:..: :|.|   ||       ::..||.|...:.::|         :..|
 Worm   539 IFDIASHWWLNLEENMPVIQELPE---NQ-------IIDHTPLTEREETMIV---------QDLA 584

  Fly   376 NERVPRSHSVGSIRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVS 440
            :|:       ....:.|..::|..|:|.|......||    ......:|.:.|...|
 Worm   585 DEQ-------DVFMEFGHLSSETRRKIEDFRIRRKEA----EEFNDNSPVKPPKARK-------- 630

  Fly   441 TENAAGTTAKKKEKPANSSFVISKDGAPLTEAPPTIIEPQATLME-----------------AET 488
            |:...|..:|::.:...|: ..|..|....:..|.:::|...|..                 |:|
 Worm   631 TDELTGKISKEQPEEMKSA-EKSLRGVKEEKEKPKVVDPNDPLERLRQIENRLGQNKKDKEAAKT 694

  Fly   489 IANI-------------PEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPAPTPVARQPTRG 540
            .|.:             ||:.|....:.:......|        :..|:..|....|...:|.|.
 Worm   695 SARVETVKLKEVKKEKSPEQQPEDPKTARGTSKPAD--------SRAPSFVPVKDRPETSEPERP 751

  Fly   541 K--------------------LDAVVETPEEKDATKVIKKFVNKH---KTADLVNAINESASKAA 582
            :                    ::.|:|..|:......|...:..|   .|..:|..:.||
 Worm   752 RTRPHLTASAYRIETDSLNMLMNQVLEQMEKGPVNLNIIARIKAHPLYDTRPMVKELLES----- 811

  Fly   583 APVSAVAPPPFVRKCS-LQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGV 646
              :.|..|.|..::.| :.::.|.::.|...||.:    .:..:...|...:|..|.|:.....|
 Worm   812 --IIAAQPEPVQKQTSKVVEQQTFSRQNTLTRKKK----EDPLEEEIPEVPSPSRKMKERPWHSV 870

  Fly   647 SVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAA------------AAQEAETLSTP---- 695
            .|| |..:.|             |...|.||.:|:.|.            ::.|.|...||
 Worm   871 EVG-FDPDEE-------------PEHDRMQESIASNATEVTVQDTSFEDDSSDEEERKKTPVAST 921

  Fly   696 PPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIGVSEPA 760
            |.:||:.  :|..:|..:......||              ..:.|..|:::|..:.:..|.|:
 Worm   922 PKTPVLI--VEKQESSTNAEDEESDE--------------GDDYSDAEMEELADEVDKKGPSD-- 968

  Fly   761 TQQERERKLKNARAIIGNAIQPVIRR--------PTPFYGIGNGFGNGMGGAVGASGATVNNAPK 817
                             :.:.||:..        |:......:.|..|:          :....|
 Worm   969 -----------------SKLAPVVENLEANPPPDPSSSPQFLDAFDRGL----------IKRQSK 1006

  Fly   818 RAQSGSSFMGYSGATSPGTAATSPP-----ISGPQTAPPVLISPNALAVAKQTIQ----QRIFGG 873
            .....:....|....|  |...||.     ..|||  |...:||.....||:.:|    .::...
 Worm  1007 GKYQHTLINNYGRGVS--TECESPTQQRKFFGGPQ--PSAELSPFLFDKAKEILQTYPNNKLDAR 1067

  Fly   874 GL--------------------PSPNNQPANRRPATWQPQASYSTASIFQPPQSQSSPFKMLQQQ 918
            |:                    |...::|.|....:..|::        .||....|..:.|..:
 Worm  1068 GIDVELRRKLRMEKVKADLLKQPKDGDKPRNSYVGSVPPRS--------PPPIVVKSDGEELDDE 1124

  Fly   919 YQQRCQE------DQKQSCPFT--PPPSPQNAASHAYAAQANSNNYGGNSNSGASGGSSSNSRCN 975
            .::...|      |.::...|.  .|..|..||.              ..:.||
 Worm  1125 EEEEEDEEEIEETDSEEGSDFENFKPKRPIIAAV--------------RRDDGA----------- 1164

  Fly   976 SSNIGNCNTMPYVNYNVNSRTRPFNHNQAQDTLNTNANTSASATCALPVAMWLKSSPGAEGPPTP 1040
                    .:|.    ::..|||                             ...||.::.|...
 Worm  1165 --------VVPV----IHQTTRP-----------------------------AVVSPNSQNPRYQ 1188

  Fly  1041 PGAVKTSTASITLKSATLPRRKINAKAEVQLDIKPRIPEQGAPPQPAMRFSTEMQHPVADLRSAP 1105
            ..:.||||.             |.|..|       ::|..|.        |.:....||:|:..|
 Worm  1189 VASPKTSTV-------------IQATPE-------KVPVAGT--------SAKYLVTVAELKLKP 1225

  Fly  1106 PREGPIPYSPIKTTLQARATSLEPKEHVITIQRPPTQHAYGRTSSNTTTRSGSLSRQSTVESESE 1170
            ..:        |...|.:.   :.|:..|..:|..|:.|                ..||:..:|:
 Worm  1226 TDK--------KEEAQLKE---QLKDSEINSERKVTKGA----------------APSTISQDSD 1263

  Fly  1171 GTTTATNMS-------------QATITSTSQPIKKSPREFIIP---------------------- 1200
            |..|..:.|             ..||.:..:.::...|..:.|
 Worm  1264 GKDTFESASAYIRRKNRERRQRNRTIGTAEEALRALERPSVDPYDDRAFSPLSTDPFYSHHSSGS 1328

  Fly  1201 IAVEGGGFITPRERSVEPSESSHTTSSRSTFTRLRPSRRIGSLLSEAGFDEGSPFQKMRTTS--- 1262
            .|....|::.||..     :.|:.|...|.:..:.|:.|..:.::.....:.:.:....||.
 Worm  1329 AAPSALGYVRPRYH-----DDSYRTHRDSDYRPMSPTSRYTAAVTRDDRGKSTSYDPHETTRPSY 1388

  Fly  1263 ----ITRDGVSGG---------------------------AEEEA-RFTPH-------------- 1281
                ||....|..                           ||.:| |.|.|
 Worm  1389 DRGYITSSNASPSYTRKFEHEQPTLNSWANDRKFEVYKTRAERDAERNTYHPTGTTGASSYRPSS 1453

  Fly  1282 --RLRSSRPVKKISQDNDSQSSN--------EEDDDDDDGFEILT--AENLFSTLLQRVRALTNR 1334
              ...|.|||..:.:..:|.:|:        ......:|.:.|.|  |||..|::..|.|....|
 Worm  1454 YYTSASDRPVTGLRRPEESYTSSTNYGRYDGRSTTPSNDQYAISTALAENQASSMNNRFRPTARR 1518

  Fly  1335 LNVNSDLTAGFPSHSSRLLTDISRQAQSHSPFWSPGSPFASVLRSQVSYTYSETVEKKKVRLNSS 1399
            :              :..:||..|:....|         .|:.|::|.|.|...:..   ||.:.
 Worm  1519 V--------------ASAMTDADRRNYHRS---------RSMDRNKVDYEYGSNLLN---RLTTP 1557

  Fly  1400 NSSGLGAPWRHSMSRDLGSDMESMFSRTGATLPRGHHQGKGKPSSAPAQVEKGAATVCSASTAKS 1464
            :|.|   .:.:....|      |...|:..||.:     .|:|                .|..|:
 Worm  1558 DSHG---DYSYVNYHD------SSNGRSNITLEK-----DGQP----------------RSILKN 1592

  Fly  1465 EEPLDLADLDLSRLRLSKKDLETLSSITP--GLPKCFQEQLLAKLPPTQARKLSRTLSVQTSAPS 1527
            ::..|:             :....||..|  |:...|:             :|.|.||::.|...
 Worm  1593 KQSADI-------------EPRVESSYEPSNGVRSVFE-------------RLRRHLSLEKSVSP 1631

  Fly  1528 SASTPKVYKRSQSSGRGYQPEQQPQEELAKPLTTDAPKTTSASTAIYRRSLSRSQA--------- 1583
            .......|.| |.......|..:..:..:..|  |.||...:..:..||..|..:.
 Worm  1632 QRQNTSFYGR-QLRVASVGPHSRNIDSTSSAL--DNPKKKRSLLSFNRRKTSEVRMGADGKLVTN 1693

  Fly  1584 ---PTPNSGQDADSRAAPTPKSRSSSVCRDDYGKSSLCSSSTYTSDISEKYKYYSPYLSKSSNVS 1645
               .||:|   .|.:...:|..|..|:.|.:.      ||.|..||.....:.|:.....|:...
 Worm  1694 GYDSTPSS---RDFKRPSSPIDRIKSLFRKNE------SSGTGHSDYYNSSRNYTSSNPVSTTRE 1749

  Fly  1646 PSIASKDAPEKRYSGGLGRPPSGCLSPPPQLPQVAATEGTSSLRAGRSSQRRISRFLRPDFFDEP 1710
            |.:|.    .::|.|...|..|..|:.....|             |.:.|||       .::|:|
 Worm  1750 PYVAQ----YRKYPGSTSRDTSSALNRYSYTP-------------GLTDQRR-------HWYDDP 1790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	172/252 (68%)
unc-82	NP_001255294.1	STKc_NUAK	295..548	CDD:270975	173/258 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002307
OrthoInspector	1	1.000	-	-		oto18364
orthoMCL	1	0.900	-	-		OOG6_106932
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5135
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930