Protein Alignment Nuak and Mark3

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: XP_006515574.1
• Gene: Mark3 / 17169
• MGIID: 1341865
• Length: 806
• Species: Mus musculus
• Alignment Length: 805
• Identity: 217/805 - (26%)
• Similarity: 360/805 - (44%)
• Gaps: 167/805 - (20%)

  Fly    29 TGNSLAHPSGIPQDQIDNIMSG------IANTGNVK--MNNHRKKLRQRFDIIKKLGQGTYGKVQ 85
            |.|.::|..|..:.......||      ||:..:.:  :.|:|        ::|.:|:|.:.||:
Mouse    15 TENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYR--------LLKTIGKGNFAKVK 71

  Fly    86 LGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFA 150
            |..:..||:|||||.|.|.::. ...|.::.|||:||..::||||:.::||.|..:.:.|:||:|
Mouse    72 LARHILTGREVAIKIIDKTQLN-PTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYA 135

  Fly   151 AGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLS 215
            :|||::|||.....:.|:|||..|||:.:||.|||:.:|.|||||.||:|||...|.||||||.|
Mouse   136 SGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS 200

  Fly   216 NVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQI 280
            |.|.....|.||||||.||:||:.:|..|.|||||.|||||:|||||.||:||||.|.|.|.:::
Mouse   201 NEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265

  Fly   281 SQGDYYEPRKPSRAST----LIRDMLTVCPRKRASIEQICSHWWVN---ENDNVSCLDLAE-DLA 337
            .:|.|   |.|...||    |::..|.:.|.||.::|||....|:|   |.|.:......| |::
Mouse   266 LRGKY---RIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDIS 327

  Fly   338 NQTPVRLDVLLSLTPA--------------TITADQLVVPSAEGAAAAKAAANERVPRSH-SVGS 387
            :|.  |:|:::.:..:              .|||..|::    |..:|:..|::....|: |:..
Mouse   328 DQK--RIDIMVGMGYSQEEIQESLSKMKYDEITATYLLL----GRKSAELDASDSSSSSNLSLAK 386

  Fly   388 IRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKK 452
            :|    ||:       |:..:.|:     ||......:.|..|.:|:..........:.....|:
Mouse   387 VR----PNS-------DLSNSTGQ-----SPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKR 435

  Fly   453 EKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANI--PEEVPVPSYSQKDMQAVGDICDL 515
            .:.:.:...:.:||.|..::..:.:..:.....:..:.|.  |.:..:|...:
Mouse   436 SQTSTADSDLKEDGIPSRKSSSSAVGGKGIAPASPMLGNAGNPNKADIPERKK------------ 488

  Fly   516 LMGTATTPAPAPPAPTPVARQPTR-----------GKLDAVVETPEEKDATKVIKKFVNKHKTAD 569
                    :||.|:....:...||           ....:|::..:|
Mouse   489 --------SPAVPSSNTASGGMTRRNTYVCSERCAADRHSVIQNGKE------------------ 527

  Fly   570 LVNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAP 634
              |::.|..:.||:|.|..|    ...|.|:.:.::: .:|......:|         ||: .:.
Mouse   528 --NSLTEVFAYAASPASLCA----TSTCRLRHQRSMS-VSASGHPKMVL---------PPI-DSE 575

  Fly   635 PEKPKKLSIPGVSVGSFKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAA-----AAQEAETLST 694
            .:..|.::||        .|....|:....:...||..:|.....|:.:.     ..:...|.:.
Mouse   576 GDTFKAIAIP--------DERTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNG 632

  Fly   695 PPPSPVV---AQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQTETIG- 755
            ||.||.:   |..|..:.|:.|.          ::.:.:...|..:|.|.:.:.:|..:.|..|
Mouse   633 PPASPSLSHEATPLSQTRSRGST----------NLFSKLTSKLTRRNMSFRFIKRLPTEYERNGR 687

  Fly   756 -------VSEPATQQERERKLKNAR 773
                   ||.....:.||.|.::.|
Mouse   688 YEGSSRNVSSEQKDENREAKPRSLR 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	122/256 (48%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	124/263 (47%)
		UBA_MARK3_4	325..367	CDD:270590	9/47 (19%)
		MARK1-3_C	707..804	CDD:213381	2/6 (33%)