Protein Alignment Nuak and Mark3

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: XP_006240625.1
• Gene: Mark3 / 170577
• RGDID: 619883
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 811
• Identity: 215/811 - (26%)
• Similarity: 354/811 - (43%)
• Gaps: 179/811 - (22%)

  Fly    29 TGNSLAHPSGIPQDQIDNIMSG------IANTGNVK--MNNHRKKLRQRFDIIKKLGQGTYGKVQ 85
            |.|.::|..|..:.......||      ||:..:.:  :.|:|        ::|.:|:|.:.||:
  Rat    15 TENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYR--------LLKTIGKGNFAKVK 71

  Fly    86 LGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFA 150
            |..:..||:|||||.|.|.::. ...|.::.|||:||..::||||:.::||.|..:.:.|:||:|
  Rat    72 LARHILTGREVAIKIIDKTQLN-PTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYA 135

  Fly   151 AGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLS 215
            :|||::|||.....:.|:|||..|||:.:||.|||:.:|.|||||.||:|||...|.||||||.|
  Rat   136 SGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS 200

  Fly   216 NVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQI 280
            |.|.....|.||||||.||:||:.:|..|.|||||.|||||:|||||.||:||||.|.|.|.:::
  Rat   201 NEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265

  Fly   281 SQGDYYEPRKPSRAST----LIRDMLTVCPRKRASIEQICSHWWVN----ENDNVSCLDLAEDLA 337
            .:|.|   |.|...||    |::..|.:.|.||.::|||....|:|    |.:....::...|::
  Rat   266 LRGKY---RIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEEELKPFVEPELDIS 327

  Fly   338 NQTPVRLDVLLSLTPA--------------TITADQLVVPSAEGAAAAKAAANERVPRSH-SVGS 387
            :|.  |:|:::.:..:              .|||..|::    |..:|:..|::....|: |:..
  Rat   328 DQK--RIDIMVGMGYSQEEIQESLSKMKYDEITATYLLL----GRKSAELDASDSSSSSNLSLAK 386

  Fly   388 IRDMGPPNTEAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKK 452
            :|    |::       |:..:.|:     ||......:.|..|.:|:..........:.....|:
  Rat   387 VR----PSS-------DLSNSTGQ-----SPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKR 435

  Fly   453 EKPANSSFVISKDGAPLTEAPPTIIEPQATLMEAETIANI--PEEVPVPSYSQKDMQAVGDICDL 515
            .:.:.:...:.:||.|..::..:.:..:.....:..:.|.  |.:..:|...:
  Rat   436 SQTSTADSDLKEDGVPSRKSGSSAVGGKGIAPASPMLGNASNPNKADIPERKK------------ 488

  Fly   516 LMGTATTPAPAPPAPTPVARQPTR-----------GKLDAVVETPEEKDATKVIKKFVNKHKTAD 569
                    :||.|:....:...||           ....:|::..:|...|:|.
  Rat   489 --------SPAVPSSNAASGGMTRRNTYVCSERCAADRHSVIQNGKESSLTEVF----------- 534

  Fly   570 LVNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAP 634
                     :.||:|.|..|    ...|.|:.:.:::                       |:|:
  Rat   535 ---------AYAASPASLCA----TSTCRLRHQRSMS-----------------------VSAS- 562

  Fly   635 PEKPKKLSIPGVSVGSFKKEFEKKATNPPAA------EGPTPGELRAQEQVAAAAA-----AAQE 688
             ..||.:..|..|.|...|.........|.|      ...||..:|.....|:.:.     ..:.
  Rat   563 -GHPKMVLPPIDSEGDTFKAITTPDQRTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERR 626

  Fly   689 AETLSTPPPSPVV---AQSLEGSDSKNSVASISLDEARRSMENSIALLLQAQNESSKEVDQLCAQ 750
            ..|.:.||.||.:   |..|..:.|:.|.          ::.:.:...|..:|.|.:.:.:|..:
  Rat   627 TATYNGPPASPSLSHEATPLSQTRSRGST----------NLFSKLTSKLTRRNMSFRFIKRLPTE 681

  Fly   751 TETIG--------VSEPATQQERERKLKNAR 773
            .|..|        ||.....:.||.|.::.|
  Rat   682 YERNGRYEGSSRNVSSEQKDENREAKPRSLR 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	122/256 (48%)
Mark3	XP_006240625.1	STKc_MARK	55..307	CDD:270974	124/263 (47%)
		UBA_MARK3_4	325..367	CDD:270590	9/47 (19%)
		MARK1-3_C	707..804	CDD:213381	2/6 (33%)