DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and Lad1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_598425.2	Gene:	Lad1 / 16763	MGIID:	109343	Length:	528	Species:	Mus musculus

Alignment Length:	553	Identity:	123/553 - (22%)
Similarity:	196/553 - (35%)	Gaps:	132/553 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1712 DRETQSMLREIREKSI----DRQDQEQTQPQDLRRRKHSLPNVEQAEQPAETAPIRSSMRHSRNK 1772
            |.|.|...|..|.:::    |.:..:.|| ...:|....||:||:||....:.|...........
Mouse    22 DEEEQERERRRRHRNLSSTTDDESPKLTQ-NGAQRSVERLPSVEEAEVSKPSPPASKDEDEDFQA 85

  Fly  1773 SMELFTEAESNGQVRDTVKTSTSRQRSVSKARELETELD--------KHELADKILQELQLLSAV 1829
            .:....|.....||.:.|      |..|.:..|.|.|.|        ...|..|  ::::.|...
Mouse    86 ILRTRKERRQRRQVVEAV------QAPVQERPEAEEERDSLGPEQTSSQPLVPK--KKVEALPRR 142

  Fly  1830 RSQHEQ----TQESEKAEETSTIKKIKKLKPTESNEPEATKIASTTTSSTTTLVRKVKKVVKKTD 1890
            |...||    .|:.|:.:.....:..|:| |.|:...:.|.::..|..|..|.|...:.|.:|..
Mouse   143 RLSREQRGPWAQDEERLKNRELAEGEKRL-PEETVAQQKTLVSEKTPVSEKTPVPAKRLVSEKAC 206

  Fly  1891 EAPKTTGSENADLASSAPKETKLKRPKSYPMKDLGLSLKSSTDLPEPTTSLLPTKLPSKLPSGNT 1955
            .:.|.|.:|.|.|........||...|:        |:...:.:||.|...|.|..|.:......
Mouse   207 PSEKGTATEKASLTEKRHSPEKLVPEKT--------SVTEKSPVPEKTLVSLKTAAPERRSPPVL 263

  Fly  1956 NESAVEPAPRESRLMRPKSYPATKLATPKELRKVTRSGVAIPTITEAIPTPSAMPTSTSSKSTSE 2020
            .::.|....:|.:|:..|:....|                 ..::||..||.....|...::|..
Mouse   264 EKAIVSEKMQERKLVSEKASIFEK-----------------SLVSEAKLTPKKAAVSEQPQTTGG 311

  Fly  2021 EKSTSATPTGTMSAVTDAKDIVSSSSDSRPTTIKKIIKVSKKSKLMPPT------PVT-----PT 2074
            .::|:..|.|  .|:.| |...||:..|.|.               |||      |:|     |:
Mouse   312 SQATTREPRG--RALPD-KSPPSSAEQSTPA---------------PPTKASRFPPITLQVKIPS 358

  Fly  2075 ------TPTTTATTTASTTPVESSKESSPVIKPKEKSPEKKPSKGLL------------YALGQK 2121
                  ||:.|..|.:|     |.|.|||.......||.|..|:..|            ..||:|
Mouse   359 KDEDADTPSPTLLTYSS-----SLKRSSPRTISFRMSPRKDNSETPLTRSASVRLPASTVKLGEK 418

  Fly  2122 FEKLRDSAMSKE--KKAGST---------GAAASLACTQKQGSPEERSSPEKYKKN--------- 2166
            .|:...:....|  :..||:         |.|:.....:|:.|.:.|:.|...:|.
Mouse   419 LERYHTAIQRSESVRSPGSSRTEVLVTPAGVASKRHLFEKELSGQNRTEPTSIRKENLRLSGVVT 483

  Fly  2167 ------VSDTEKSQQTGLSDDKR---VDKRSRF 2190
                  :|.|:.|...|..:.::   |.||:::
Mouse   484 SRLNLWISKTQDSGDHGSQEVRKEASVTKRAQW 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975
Lad1	NP_598425.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..404		102/439 (23%)
		6 X SEK repeats	184..281		24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..528		6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12392
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100