DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and SIK1

DIOPT Version :9

Sequence 1:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster
Sequence 2:	NP_775490.2	Gene:	SIK1 / 150094	HGNCID:	11142	Length:	783	Species:	Homo sapiens

Alignment Length:	905	Identity:	237/905 - (26%)
Similarity:	359/905 - (39%)	Gaps:	225/905 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AHPSGIPQDQIDNIMSGIANTGNVKMNNHRKKLRQRF-DIIKKLGQGTYGKVQLGINKETGQEVA 97
            |.|:|..|.|                   :|.||..| ||.:.||:|.:..|:|..::.|..:||
Human     9 ADPAGQGQGQ-------------------QKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVA 54

  Fly    98 IKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSER 162
            ||.|.|.:::: ::|.:|.||||:|..::||:||.:|:|.|.::.:.:|.|||..||::|||:..
Human    55 IKIIDKTRLDS-SNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSN 118

  Fly   163 KVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTF 227
            ..|:|.|||:.|.|:.:||.|||.|.|.|||||.||:|||...:.|:||||..|.:.....|.|:
Human   119 GHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTW 183

  Fly   228 CGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPS 292
            ||||.||:||:.||..|:||::|.|||||:||.||.||:||||.|...|.:::.:|.:..|...|
Human   184 CGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMS 248

  Fly   293 R-ASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCL-----------DLAEDLANQTPVRLD 345
            : ..:|||.||.|.|.:|.:|.||..|.|:...   .||           ....:|.:.....|.
Human   249 QDCESLIRRMLVVDPARRITIAQIRQHRWMRAE---PCLPGPACPAFSAHSYTSNLGDYDEQALG 310

  Fly   346 VLLSL-TPATITADQLVVPSAEGAAAAKAAANERVPRSHSVGSIRDMGPPNTEAERRILDMVAAG 409
            ::.:| .....|.:.|...|....||......||:....           |.:..|
Human   311 IMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYR-----------NAQCAR--------- 355

  Fly   410 GEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDGAPLTEAPP 474
                  |.|.|...|..|.:......|..:||:         ..:|           |.|...|.
Human   356 ------PGPARQPRPRSSDLSGLEVPQEGLSTD---------PFRP-----------ALLCPQPQ 394

  Fly   475 TIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPAPAPPA---PTPVARQ 536
            |:::   ::::||....:...:..|.:...|....|         ...|.|..|:   .|.::.:
Human   395 TLVQ---SVLQAEMDCELQSSLQWPLFFPVDASCSG---------VFRPRPVSPSSLLDTAISEE 447

  Fly   537 PTRGKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQD 601
            ..:|.     ...||:|..:.:.....:..|   :..::...|...||...|:|
Human   448 ARQGP-----GLEEEQDTQESLPSSTGRRHT---LAEVSTRLSPLTAPCIVVSP----------- 493

  Fly   602 ESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGVSVGSFKKEFEKKATNPPAAE 666
             ||                          .|:|.|        |.|..|.   ....|:..||..
Human   494 -ST--------------------------TASPAE--------GTSSDSC---LTFSASKSPAGL 520

  Fly   667 GPTPGELRAQEQVAAAAAAAQEAETLSTPPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIA 731
            ..||.   .|..:.|.:.....:..|.:...:||:  ..:|......:..:|..|.||:.:.|:.
Human   521 SGTPA---TQGLLGACSPVRLASPFLGSQSATPVL--QAQGGLGGAVLLPVSFQEGRRASDTSLT 580

  Fly   732 LLLQAQNESSKEVDQLCAQTET---IGVSEPATQQERERKLKNARAIIGNAIQPVIRRP----TP 789
            ..|:|..:      ||...|.|   :|::          |:|.....:..|  |..|..    :|
Human   581 QGLKAFRQ------QLRKTTRTKGFLGLN----------KIKGLARQVCQA--PASRASRGGLSP 627

  Fly   790 FYGIGNGFGNGMGGAVG------------------------ASGATVNNAPKRAQSGSSFM---- 826
            |:......|. .|||.|                        |:....:.||:.|.  :.|:
Human   628 FHAPAQSPGL-HGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAP--APFVIAPC 689

  Fly   827 -GYSGATSPGTAATSPPISGPQTAPPVLISPNA--LAVAKQTIQQRIFGGGLPSPNNQPA 883
             |...|..|.|..|    ||....||.|:...|  :|.|.|.:...:..|  ..|...||
Human   690 DGPGAAPLPSTLLT----SGLPLLPPPLLQTGASPVASAAQLLDTHLHIG--TGPTALPA 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	116/254 (46%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	116/252 (46%)
		S_TKc	27..278	CDD:214567	115/251 (46%)
		UBA_SIK1	300..349	CDD:270591	10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..477		5/35 (14%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305\|PubMed:29211348	583..612		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840