Protein Alignment Nuak1 and Prkaa1

DIOPT Version :9

• Sequence 1: NP_001369005.1
• Gene: Nuak1 / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: XP_036014946.1
• Gene: Prkaa1 / 105787
• MGIID: 2145955
• Length: 589
• Species: Mus musculus
• Alignment Length: 565
• Identity: 171/565 - (30%)
• Similarity: 252/565 - (44%)
• Gaps: 162/565 - (28%)

  Fly    76 LGQGTYGKVQ------------------------------LGINKETGQEVAIKTIKKCKIEAEA 110
            ||.||:|||:                              :|.::.||.:||:|.:.:.||.:..
Mouse    33 LGVGTFGKVKVPEKGYTDARLLGTLPQQQYLNSYVHIDCLVGKHELTGHKVAVKILNRQKIRSLD 97

  Fly   111 DLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFR 175
            .:.:||||:|.:....||:||.:|:|......:.:|||:.:||||:||:.:...|.|:|:||:|:
Mouse    98 VVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 162

  Fly   176 QVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVE 240
            |:.:.|.|||:|.:.|||||.||:|||...|||||||||||:..|...|.|.||||.||:||::.
Mouse   163 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 227

  Fly   241 GTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPR--KPSRASTLIRDMLT 303
            |..|.|||||.||.||:||.|:.|::|||..:...|.|:|..|.:|.|:  .||..| |::.||.
Mouse   228 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS-LLKHMLQ 291

  Fly   304 VCPRKRASIEQICSHWW----------------------------------VNENDNVSCL---- 330
            |.|.|||:|:.|..|.|                                  .:|.:.:|||
Mouse   292 VDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRN 356

  Fly   331 -------------------DLAED----------------LANQTPVRLDVLLSLTP-ATITADQ 359
                               :.|:|                |....|.|:..|::.|| |..|.|:
Mouse   357 HQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDE 421

  Fly   360 LVVPSA--EGAAAAK--------AAANE------------------------RVPRSHSVGS-IR 389
            |....:  :|...||        :..|:                        ||.|.:.|.| ..
Mouse   422 LNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFS 486

  Fly   390 DMGPPNTEAERR--ILDMVAAGGEAALMPSPTRTITPAQS-PVQTKRKLQPTVSTENAAGTTAKK 451
            .|.....:.:.|  :||..:...|  :..:.:.|.||.:| .:...|..|.:.|...|.|
Mouse   487 KMSLQLYQVDSRTYLLDFRSIDDE--ITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQG----- 544

  Fly   452 KEKPAN---SSFVISKDGAPLTEAPPTIIEPQATLME-AETIANI 492
              ||::   :|.|.|.|.:|:..||    .|.:..:| .|..||:
Mouse   545 --KPSDVSLTSSVTSLDSSPVDVAP----RPGSHTIEFFEMCANL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	118/310 (38%)
Prkaa1	XP_036014946.1	STKc_AMPK_alpha	24..309	CDD:270981	117/276 (42%)
		UBA_AID_AAPK1	326..390	CDD:270586	6/63 (10%)
		AMPKA1_C	434..587	CDD:213384	36/163 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845716
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840