Protein Alignment Nuak and brsk1

DIOPT Version :10

• Sequence 1: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Sequence 2: XP_004916361.1
• Gene: brsk1 / 100491623
• XenbaseID: XB-GENE-1013495
• Length: 834
• Species: Xenopus tropicalis
• Alignment Length: 885
• Identity: 231/885 - (26%)
• Similarity: 363/885 - (41%)
• Gaps: 255/885 - (28%)

  Fly    74 KKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFE 138
            |.||:|..|.|:||::..|||:||||.:.:.|: :|:.|:::.||:.|:..:.||:::.:::|:|
 Frog    29 KTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVLKLHDVYE 92

  Fly   139 NREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDE 203
            |::.:.||:|..:||||:|||.::..||.:|||:.|||:.:|:.:||.:.|||||||.||:||||
 Frog    93 NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSYSICHRDLKPENLLLDE 157

  Fly   204 KGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPF 268
            |.|.:|||||::::.....||.|.||||.||.||:::|..|.|...|.||.||:|:.|:.|::||
 Frog   158 KNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADVWSCGVILFALLVGALPF 222

  Fly   269 DGSNFKRLVKQISQGDYYEPR-KPSRASTLIRDMLTVCPRKRASIEQICSHWWV----------- 321
            |..|.::|::::.:|.::.|. .|.....|:|.|:.|.|.||.|:|||..|.|.
 Frog   223 DDDNLRQLLEKVKRGVFHMPHFIPPECQNLLRGMIEVEPEKRLSLEQIQKHSWYLGGKNEPEPEQ 287

  Fly   322 ------------------------------------------NENDN----------------VS 328
                                                      ||::|                .|
 Frog   288 PTPRKVAIRRIHSVSEFDPDVLDSMHSLGCFRDKTKLKQELQNEDENQEKMIYYLLLDRKERYPS 352

  Fly   329 CLDLAEDLANQTPVRLDVLLSLTPATITADQLVVPSAEGAAAAKAAANERVP--RSHSVGSIRDM 391
            |.|  |||    |.|.|:    .|.....|..:: :..|         :|.|  :|..|.|:.|.
 Frog   353 CED--EDL----PPRNDI----DPPRKRVDSPML-NRHG---------KRRPERKSMEVLSVTDG 397

  Fly   392 GPPNTEAERRILDMV--------AAGGEAALMPSPTRTITPAQSPVQT--KRKLQPTVSTENAAG 446
            |.|  ...||.::|.        .:|....|..||   ::..:|||.|  ...|:|....:..|.
 Frog   398 GSP--VPARRAIEMAQHSQRSRSVSGASTGLSSSP---LSSPRSPVFTFSPTPLEPAEGEDPRAI 457

  Fly   447 TTAKKKEK---------PANSSF------VISKDGAPLTEA------------------PP---- 474
            ..:|...:         ||.:|.      .|..:..|:|.|                  ||
 Frog   458 WQSKAAHRQPDPKTQTLPAKTSLGEKPLHTIKSNPLPITMAASSPPHDSSSSPHRSPLSPPFFPT 522

  Fly   475 ---------------TIIEPQATLMEAETIANIPEEVPVPSYSQKDMQAVGDICDLLMGTATTPA 524
                           ::..||.|...:...:.:|..:..|.::.||            ....||:
 Frog   523 SLPARFFPGTKSATKSVPLPQVTPHPSPRGSPLPTPLGTPVHTPKD------------SPTGTPS 575

  Fly   525 PAPPAPTPVARQPTRGKLDAV----------------VETPEE------KDATKVIKK-----FV 562
            ..||:...|.....:.:|:::                |.||||      :.:.::.||     |:
 Frog   576 GTPPSSPGVGGVAWKTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSSLTPESSPELAKKSWFGNFI 640

  Fly   563 NKHKTADLVNAINESASKAAAPVSAVAPPPFVRKCSLQDESTLNK--FNAERRKSRILETAEKFQ 625
            |..|...:...|.:   |..:.:.|.....|:...|| ..|.:::  |.||.:.|
 Frog   641 NLDKEEQIFVVIKD---KPLSSIKADIVHAFLSIPSL-SHSVISQTSFRAEYKSS---------- 691

  Fly   626 PPPPVAAAPP--EKPKKLSIP-GVSVGS-FKKEFEKKATNPPAAEGPTPGELRAQEQVAAAAAAA 686
                  ..|.  :||.|..:. ..|.|: .:||....:.......||:....|..|.:
 Frog   692 ------GGPSVFQKPVKFQVDISYSEGAEAQKENGIYSVTFTLISGPSRRFKRVVETI------- 743

  Fly   687 QEAETLST-PPPSPVVAQSLEGSDSKNSVASISLDEARRSMENSIALLL-----QAQNESSKEVD 745
             :|:.||| ..||   .|:|.||:.          .||..||.|:..||     :...:.|:...
 Frog   744 -QAQLLSTHDQPS---VQALAGSNV----------TARTQMECSLDHLLFLPPDEKNGQQSRPPG 794

  Fly   746 QLCAQTETIGVSEPATQQERER---KLKNARAIIGNAIQP 782
            ......:....|||...:...|   |.|...|..|...||
 Frog   795 TPTRSCQNSRRSEPDMAEHHRRGSSKDKKLLASNGTQTQP 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	109/247 (44%)
brsk1	XP_004916361.1	STKc_BRSK1_2	23..276	CDD:270983	109/247 (44%)
		UBA_BRSK	303..356	CDD:270525	6/54 (11%)