Protein Alignment Sirt6 and cobB

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_415638.3
• Gene: cobB / 945687
• ECOCYCID: G6577
• Length: 279
• Species: Escherichia coli
• Alignment Length: 292
• Identity: 67/292 - (22%)
• Similarity: 112/292 - (38%)
• Gaps: 101/292 - (34%)

  Fly    24 FDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVW---------TLEEKGEK 79
            |..|:||.|..::        ..|::.||||||..:||..||...|:|         |.|.....
E. coli    28 FFRDKVVPEAMEK--------PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRD 84

  Fly    80 PDFNVSFDEAR----------PTKTHMAIIALIES-GYVQYVISQNIDGLHLKSGLDRKYLSELH 133
            |:...:|..||          |...|:|:..|.:: |....:::||||.||.::|  ...:..:|
E. coli    85 PELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMH 147

  Fly   134 GNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDL-PEN- 196
            |.:.                                   |.|..:||    .||||..|: ||:
E. coli   148 GELL-----------------------------------KVRCSQSG----QVLDWTGDVTPEDK 173

  Fly   197 ------------------DLEMGV----MHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVI 239
                              ::.:|:    |..::||:.||:||:..:.|:.....:....|...|.
E. coli   174 CHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVE 238

  Fly   240 CNLQPT--------KHDKKANLIISSYVDVVL 263
            .||:|:        |:...|:.::..:|:.:|
E. coli   239 LNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	60/264 (23%)
cobB	NP_415638.3	PRK00481	31..271	CDD:234777	66/289 (23%)