DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and Sirt1

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_062786.1	Gene:	Sirt1 / 93759	MGIID:	2135607	Length:	737	Species:	Mus musculus

Alignment Length:	281	Identity:	60/281 - (21%)
Similarity:	120/281 - (42%)	Gaps:	36/281 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWT--LEEKGEKPDFNVSFD---------- 87
            ::..:|:::...:::.||||:|.|.||||||...|::.  ..:..:.||....||
Mouse   236 EDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRP 300

  Fly    88 -----------EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQC 141
                       :.:|:..|..|....:.|.:....:||||.|...:|:.|  :.:.||:.....|
Mouse   301 FFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--ILQCHGSFATASC 363

  Fly   142 KKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHST 206
            ..|:.:....:....:..:.:.|..:...|..     ..|:...::.:..:|||...........
Mouse   364 LICKYKVDCEAVRGDIFNQVVPRCPRCPADEP-----LAIMKPEIVFFGENLPEQFHRAMKYDKD 423

  Fly   207 VADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLG 271
            ..||.|.:|::|::.|...:| .::......::.|.:|..| ...::.:....||:::::|..||
Mouse   424 EVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH-LHFDVELLGDCDVIINELCHRLG 486

  Fly   272 VEIPEYSE-ASDPTKQSKPME 291
               .||:: ..:|.|.|:..|
Mouse   487 ---GEYAKLCCNPVKLSEITE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	48/235 (20%)
Sirt1	NP_062786.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Interaction with H1-4. /evidence=ECO:0000250\|UniProtKB:Q96EB6	2..268		13/31 (42%)
		Interaction with CLOCK. /evidence=ECO:0000269\|PubMed:18662547	2..131
		Nuclear localization signal	32..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..125
		Interaction with CCAR2. /evidence=ECO:0000250\|UniProtKB:Q96EB6	135..533		60/281 (21%)
		Nuclear export signal	138..145
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..171
		Nuclear localization signal	223..230
		SIRT1	246..481	CDD:238699	50/243 (21%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000250\|UniProtKB:Q96EB6	248..251		0/2 (0%)
		Nuclear export signal	425..431		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..713
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810