Protein Alignment Sirt6 and HST2

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_015310.1
• Gene: HST2 / 856092
• SGDID: S000005936
• Length: 357
• Species: Saccharomyces cerevisiae
• Alignment Length: 267
• Identity: 75/267 - (28%)
• Similarity: 113/267 - (42%)
• Gaps: 53/267 - (19%)

  Fly    47 VVLHTGAGISTSAGIPDFRGP-KGVW----TLEEKGEKPDFNVSFDEA----------------- 89
            |:...|||||||.||||||.| .|::    .|:....:..|:|.|.::
Yeast    27 VIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNF 91

  Fly    90 RPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAV 154
            ||:|.|..:....:...::.|.:||||.|..::|:....:.|.||:.....|..|.:  |.|..|
Yeast    92 RPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGK--VYPPQV 154

  Fly   155 ETVGQKSLQRACKS--SMDSKGRSCRSGILYDNVLDWEHDLPE-------NDLEMGVMHSTVA-- 208
              ...|..:...|.  ..|..|...:..|::     :..|||:       ||.|......|.:
Yeast   155 --FKSKLAEHPIKDFVKCDVCGELVKPAIVF-----FGEDLPDSFSETWLNDSEWLREKITTSGK 212

  Fly   209 ----DLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKAN-----LIISSYVDVVLS 264
                .|.|.:||:|.:.|...|| :.:....|.|:|||: |..|.|||     ||:..|.|....
Yeast   213 HPQQPLVIVVGTSLAVYPFASLP-EEIPRKVKRVLCNLE-TVGDFKANKRPTDLIVHQYSDEFAE 275

  Fly   265 KVCKLLG 271
            ::.:.||
Yeast   276 QLVEELG 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	71/252 (28%)
HST2	NP_015310.1	SIRT1	26..277	CDD:238699	73/260 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54280
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820