Protein Alignment Sirt6 and HST3

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_014668.1
• Gene: HST3 / 854190
• SGDID: S000005551
• Length: 447
• Species: Saccharomyces cerevisiae
• Alignment Length: 382
• Identity: 91/382 - (23%)
• Similarity: 153/382 - (40%)
• Gaps: 115/382 - (30%)

  Fly    17 ILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGV----------- 70
            |:|    .|:|:   |..:.:.:.:.:|..:...||||||.:|||||||...|:
Yeast    32 IIG----LDADD---EVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQY 89

  Fly    71 WTLEEKGE-------KPDFNVS----FDE--------ARPTKTHMAIIALIESGYVQYVISQNID 116
            |:::...|       :.||.:|    |.|        |:|||||..|..|.:...:....:||||
Yeast    90 WSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNID 154

  Fly   117 GLHLKSGL---DRKY-------------LSELHGNIYIEQCKKCRRQFVSP-----SAVETVGQK 160
            ||....||   :||.             :.:|||::....|.||.:.|  |     |.....|:.
Yeast   155 GLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTF--PWSRYWSRCLRRGEL 217

  Fly   161 SLQRACKSSMD---SKGR---SCRSGILYDNVLDWEHDLPE-----NDLEMGVMHSTVADLNIAL 214
            .|...|::.::   ::|:   ....|||..|::.:..:.|.     ..|.:.::... .|..|.:
Yeast   218 PLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGN-PDFLIIM 281

  Fly   215 GTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLII--------SSY---VDVVLSKVC- 267
            ||:|::            .|.|.::..|....||:...:|:        ||:   :|..:...|
Yeast   282 GTSLKV------------DGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQIHSDCD 334

  Fly   268 ---KLLGVEIPEYSEASDPTKQSKPMEWTIPTSNVNTFHRQYKKYVKDSKIESKAKK 321
               ..|..:||::.:..|..|:.                ||.|:...|.:.:.||:|
Yeast   335 NWVTFLESQIPDFFKTQDQIKKL----------------RQLKREASDLRKQMKAQK 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	70/282 (25%)
HST3	NP_014668.1	SIR2	42..349	CDD:223915	77/321 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810