Protein Alignment Sirt6 and HST1

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_014573.1
• Gene: HST1 / 854086
• SGDID: S000005429
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 289
• Identity: 64/289 - (22%)
• Similarity: 111/289 - (38%)
• Gaps: 69/289 - (23%)

  Fly    41 IKKSGHVVLHTGAGISTSAGIPDFRG---------------PKGVWTLEEKGEKPD--FNVSFDE 88
            ::.:..:::.||||:|||.||||||.               |:.|:.|:...:.|.  :|::...
Yeast   197 LRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMV 261

  Fly    89 ARP----TKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFV 149
            ..|    :..|..|..|.:.|.:....:||||.|...:|:|...|.:.||:.....|..|..|..
Yeast   262 LPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIP 326

  Fly   150 SPSAVETVGQKSL--------QRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEM------ 200
            .....|.:....|        :|.....|.:...:.::.|.:::.:...:.:.:.|:..
Yeast   327 GEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALP 391

  Fly   201 GVMHSTV------ADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQP-------------TK 246
            ...|.|:      .||.|.:||:|::.|..:             |.|:.|             |.
Yeast   392 SRFHKTIRKDILECDLLICIGTSLKVAPVSE-------------IVNMVPSHVPQILINRDMVTH 443

  Fly   247 HDKKANLIISSYVDVVLSKVCKLLGVEIP 275
            .:...||:  .:.|.|.|.|.|....:||
Yeast   444 AEFDLNLL--GFCDDVASLVAKKCHWDIP 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	57/266 (21%)
HST1	NP_014573.1	DUF592	53..207	CDD:368003	0/9 (0%)
		SIRT1	201..461	CDD:238699	60/274 (22%)