DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sirt6 and HST1

DIOPT Version :9

Sequence 1:NP_649990.2 Gene:Sirt6 / 41254 FlyBaseID:FBgn0037802 Length:325 Species:Drosophila melanogaster
Sequence 2:NP_014573.1 Gene:HST1 / 854086 SGDID:S000005429 Length:503 Species:Saccharomyces cerevisiae


Alignment Length:289 Identity:64/289 - (22%)
Similarity:111/289 - (38%) Gaps:69/289 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 IKKSGHVVLHTGAGISTSAGIPDFRG---------------PKGVWTLEEKGEKPD--FNVSFDE 88
            ::.:..:::.||||:|||.||||||.               |:.|:.|:...:.|.  :|::...
Yeast   197 LRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMV 261

  Fly    89 ARP----TKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFV 149
            ..|    :..|..|..|.:.|.:....:||||.|...:|:|...|.:.||:.....|..|..|..
Yeast   262 LPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIP 326

  Fly   150 SPSAVETVGQKSL--------QRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEM------ 200
            .....|.:....|        :|.....|.:...:.::.|.:::.:...:.:.:.|:..      
Yeast   327 GEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALP 391

  Fly   201 GVMHSTV------ADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQP-------------TK 246
            ...|.|:      .||.|.:||:|::.|..:             |.|:.|             |.
Yeast   392 SRFHKTIRKDILECDLLICIGTSLKVAPVSE-------------IVNMVPSHVPQILINRDMVTH 443

  Fly   247 HDKKANLIISSYVDVVLSKVCKLLGVEIP 275
            .:...||:  .:.|.|.|.|.|....:||
Yeast   444 AEFDLNLL--GFCDDVASLVAKKCHWDIP 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt6NP_649990.2 SIRT7 45..258 CDD:238701 57/266 (21%)
HST1NP_014573.1 DUF592 53..207 CDD:368003 0/9 (0%)
SIRT1 201..461 CDD:238699 60/274 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0846
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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