Protein Alignment Sirt6 and HST4

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_010477.3
• Gene: HST4 / 851772
• SGDID: S000002599
• Length: 370
• Species: Saccharomyces cerevisiae
• Alignment Length: 320
• Identity: 76/320 - (23%)
• Similarity: 130/320 - (40%)
• Gaps: 89/320 - (27%)

  Fly    24 FDSDEVV----AEKCQE---------LAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEE 75
            ||.|..|    ..|.|.         ::..:..|..:|:.:|||||.:|||||||..:|:::...
Yeast    59 FDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVN 123

  Fly    76 KGEKPD------------FNVSFDE-----------ARPTKTHMAIIALIESGYVQYVISQNIDG 117
            .|...|            .::.|::           .:|||.|..:......|.:..:.:|||||
Yeast   124 GGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDG 188

  Fly   118 L-----HLKSG--LDRKYLS--ELHGNIYIEQCKKC------------------RRQFVSPSAVE 155
            |     ||.:.  |.:...|  :|||:|...:|.||                  .|..:.||..:
Yeast   189 LDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDKFDSRTEIIPSCPQ 253

  Fly   156 TVGQKSLQRACKSSMDSKGRSCRSGILYDNVL---DWEHDLPENDLEMGVMHSTVADLNIALGTT 217
            ....:::::.........|:.....|||:.|.   |:..::..|||:..:      |..|.:||:
Yeast   254 CEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRI------DCLIIVGTS 312

  Fly   218 LQIVPSGDLPLKNLKC--------GGKFVICNLQPTKHDKKANLIIS-SYVDVVLSKVCK 268
            |:| |.    :||: |        ..:.::..|..:...|  |::.| .:||:|:...|:
Yeast   313 LKI-PG----VKNI-CRQFAAKVHANRGIVLYLNTSMPPK--NVLDSLKFVDLVVLGDCQ 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	65/274 (24%)
HST4	NP_010477.3	SIR2	77..370	CDD:223915	70/302 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810