Protein Alignment Sirt6 and SIR2

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_010242.1
• Gene: SIR2 / 851520
• SGDID: S000002200
• Length: 562
• Species: Saccharomyces cerevisiae
• Alignment Length: 326
• Identity: 68/326 - (20%)
• Similarity: 122/326 - (37%)
• Gaps: 89/326 - (27%)

  Fly    47 VVLHTGAGISTSAGIPDFRGPKGVWT------LEEKGEKPDFNVSFDEAR-----------PTKT 94
            :::.||||:|||.||||||..:|.::      |::..:..::|:...:..           |.|.
Yeast   257 ILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKI 321

  Fly    95 HMAIIALIE----SGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC----------- 144
            :..:.:.|:    .|.:....:||||.|...:|:....|.:.||:.....|..|
Yeast   322 YSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFN 386

  Fly   145 ----------------RRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRS--GILYDNVLDWEH 191
                            ||::........||    ..|.:.||..:.....:  |:|..::..:..
Yeast   387 KIRNLELPLCPYCYKKRREYFPEGYNNKVG----VAASQGSMSERPPYILNSYGVLKPDITFFGE 447

  Fly   192 DLPENDLEMGVMHSTV------ADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKK 250
            .||..      .|.::      .||.|.:||:|::.|..:: :..:......|:.|..|.|| .:
Yeast   448 ALPNK------FHKSIREDILECDLLICIGTSLKVAPVSEI-VNMVPSHVPQVLINRDPVKH-AE 504

  Fly   251 ANLIISSYVDVVLSKVCKLLGVEIPEYSEASDPTKQSKPMEWTIPTSNVNTF-HRQYKKYVKDSK 314
            .:|.:..|.|.:.:.|.:..|                    ||||....|.. ::.:|...||..
Yeast   505 FDLSLLGYCDDIAAMVAQKCG--------------------WTIPHKKWNDLKNKNFKCQEKDKG 549

  Fly   315 I 315
            :
Yeast   550 V 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	56/266 (21%)
SIR2	NP_010242.1	DUF592	104..261	CDD:368003	0/3 (0%)
		SIRT1	255..517	CDD:238699	58/271 (21%)