DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and SRT1

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_200387.1	Gene:	SRT1 / 835670	AraportID:	AT5G55760	Length:	473	Species:	Arabidopsis thaliana

Alignment Length:	328	Identity:	140/328 - (42%)
Similarity:	202/328 - (61%)	Gaps:	25/328 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFR 65
            ||..||:.||..::.|.:|..|.||...::..|.:|||:||:||.|:|:.||||||||.||||||
plant     1 MSLGYAEKLSFIEDVGQVGMAEFFDPSHLLQCKIEELAKLIQKSKHLVVFTGAGISTSCGIPDFR 65

  Fly    66 GPKGVWTLEEKG-EKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYL 129
            ||||:|||:.:| :.|..::.|..|.|:.||||::.|..:|.:::|||||:|||||:||:.|:.|
plant    66 GPKGIWTLQREGKDLPKASLPFHRAMPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKL 130

  Fly   130 SELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLP 194
            |||||:.::|.|..|..:::....|||:|.|...|.|  |::..|..     |.|.|||||..||
plant   131 SELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRKC--SVEKCGAK-----LKDTVLDWEDALP 188

  Fly   195 ENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYV 259
            ..:::....|...|||.:.|||:|||.|:.:||||.||.|||.||.|||.|..|||||::|...|
plant   189 PKEIDPAEKHCKKADLVLCLGTSLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLV 253

  Fly   260 DVVLSKVCKLLGVEIPEY------------SEASDPTKQSKPMEWTIPTSNVNTFHRQYKKYVKD 312
            |.|::.|.:.|.::||.|            |.:.|    .:.:.||:..::|:....|. .::|.
plant   254 DKVVAGVMESLNMKIPPYVRIDLFQIILTQSISGD----QRFINWTLRVASVHGLTSQL-PFIKS 313

  Fly   313 SKI 315
            .::
plant   314 IEV 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	106/213 (50%)
SRT1	NP_200387.1	SIRT7	45..252	CDD:238701	106/213 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	118	1.000	Domainoid score	I1943
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6924
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1025
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1503290at2759
OrthoFinder	1	1.000	-	-		FOG0006144
OrthoInspector	1	1.000	-	-		oto3903
orthoMCL	1	0.900	-	-		OOG6_104149
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830