Protein Alignment Sirt6 and Sirt5

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: XP_006517014.1
• Gene: Sirt5 / 68346
• MGIID: 1915596
• Length: 350
• Species: Mus musculus
• Alignment Length: 228
• Identity: 59/228 - (25%)
• Similarity: 96/228 - (42%)
• Gaps: 37/228 - (16%)

  Fly    30 VAEKCQELAELIK---KSGHVVLHTGAGISTSAGIPDFRGPKGVW---------TLEEKGEKPDF 82
            :|.....:|:..|   .:.|:.:.:|||:|..:|:|.|||..|.|         |.:.....|..
Mouse    33 MARPSSNMADFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFARNPSQ 97

  Fly    83 NVSFDEAR--------PTKTHMAI----IALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGN 135
            ...|...|        |...|:||    ..|.:.|....||:||||.||.|:|  .|.|.|:||.
Mouse    98 VWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAG--TKNLLEIHGT 160

  Fly   136 IYIEQCKKC---RRQFVSPSAVETVGQKSLQ---RACKSSMDSKGR----SCRSGILYDNVLDWE 190
            ::..:|..|   ...:.||......|:.:.:   :..:..:|...|    .| .|:|..:|:.:.
Mouse   161 LFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGC-GGLLRPHVVWFG 224

  Fly   191 HDLPENDLEMGVMHSTVADLNIALGTTLQIVPS 223
            .:|....||.......:.||.:.:||:..:.|:
Mouse   225 ENLDPAILEEVDRELALCDLCLVVGTSSVVYPA 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	56/210 (27%)
Sirt5	XP_006517014.1	SIRT5_Af1_CobB	51..289	CDD:238703	56/210 (27%)