Protein Alignment Sirt6 and Sirt3

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001171275.1
• Gene: Sirt3 / 64384
• MGIID: 1927665
• Length: 334
• Species: Mus musculus
• Alignment Length: 275
• Identity: 77/275 - (28%)
• Similarity: 116/275 - (42%)
• Gaps: 60/275 - (21%)

  Fly    35 QELAELI--KKSGHVVLHTGAGISTSAGIPDFRGP-KGVWT------------LEEKG-----EK 79
            |::|||:  :....||:..||||||.:||||||.| .|:::            :.|.|     .|
Mouse    61 QDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPK 125

  Fly    80 PDFNVSFD----EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQ 140
            |.|.::.:    ..||..||..:..|.:...:..:.:||||||...||:....|.|.||......
Mouse   126 PFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTAT 190

  Fly   141 CKKCRRQFVSPSAVETVGQKSLQR--ACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVM 203
            |..|||.|........|....:.|  .|            :|::..:::.:...||...| :.:.
Mouse   191 CTVCRRSFPGEDIWADVMADRVPRCPVC------------TGVVKPDIVFFGEQLPARFL-LHMA 242

  Fly   204 HSTVADLNIALGTTLQIVPSGDLP----------LKNLKCGGKFVICNLQPTKHDKKANLIISSY 258
            ...:|||.:.|||:|::.|...|.          |.|....|.||   |.|.:.|      :...
Mouse   243 DFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFV---LSPRRKD------VVQL 298

  Fly   259 VDVV--LSKVCKLLG 271
            .|||  :.::..|||
Mouse   299 GDVVHGVERLVDLLG 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	67/246 (27%)
Sirt3	NP_001171275.1	SIRT1	74..308	CDD:238699	70/255 (27%)