Protein Alignment Sirt6 and sirt7

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001015815.1
• Gene: sirt7 / 548532
• XenbaseID: XB-GENE-1005195
• Length: 393
• Species: Xenopus tropicalis
• Alignment Length: 286
• Identity: 101/286 - (35%)
• Similarity: 145/286 - (50%)
• Gaps: 47/286 - (16%)

  Fly    22 ESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVSF 86
            |..|..:::.||..:||...:.:.|||::|||||||:|.|||:|||.|||||..||...:.. ..
 Frog    72 EVLDDTDLLREKVLQLAGAFRAAEHVVIYTGAGISTAAAIPDYRGPSGVWTLLNKGRTVNAG-DL 135

  Fly    87 DEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSP 151
            .||:||.|||.|:.|..:|.||:::|||.|||||:|||.|:.:||:|||::||.|..|..|....
 Frog   136 SEAQPTFTHMCIVRLHSAGLVQHIVSQNCDGLHLRSGLPREAISEVHGNMFIEVCTLCSPQKEYV 200

  Fly   152 SAVETVGQKSLQRACKSSMDSKGRSCRS--GILYDNV------------LDWEHDLPENDLEMGV 202
            ...:...:.:|.|      .:.||.|.:  ..|.|::            |:||.         .|
 Frog   201 RLFDVTERTALHR------HNTGRFCHNCGAELRDSIVHFGERGKLTQPLNWEG---------AV 250

  Fly   203 MHSTVADLNIALGTTLQIVPSGDLPLKNLKC----------GGKFVICNLQPTKHDKKANLIISS 257
            ..|..||:.:.||::|::       ||...|          ..|..|.|||.|..|..|.|.|:.
 Frog   251 QASEKADVILCLGSSLKV-------LKKYSCLWGMNRARARRPKLYIVNLQWTPKDSVATLKING 308

  Fly   258 YVDVVLSKVCKLLGVEIPEYSEASDP 283
            ..|.|:..:.:.|.:.:|.|..:.||
 Frog   309 KCDDVMQILMEELNLNVPVYDRSQDP 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	88/236 (37%)
sirt7	NP_001015815.1	SIR2	95..309	CDD:444738	88/236 (37%)