Protein Alignment Sirt6 and SIRT6

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_057623.2
• Gene: SIRT6 / 51548
• HGNCID: 14934
• Length: 355
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 149/302 - (49%)
• Similarity: 201/302 - (66%)
• Gaps: 12/302 - (3%)

  Fly     1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFR 65
            ||.|||.|||.|.:||..|.||.||..|.:..|..|||.|:.:|..||.||||||||::||||||
Human     1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFR 65

  Fly    66 GPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLS 130
            ||.||||:||:|..|.|:.:|:.||||:||||::.|...|.:::::|||:||||::||..|..|:
Human    66 GPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLA 130

  Fly   131 ELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPE 195
            |||||:::|:|.||:.|:|..:.|.|:|.|:..|.|..:.....|:|| |.|.|.:||||..||:
Human   131 ELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACR-GELRDTILDWEDSLPD 194

  Fly   196 NDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVD 260
            .||.:....|..|||:|.|||:|||.|||:|||...:.||:.||.||||||||:.|:|.|..|||
Human   195 RDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVD 259

  Fly   261 VVLSKVCKLLGVEIPEYSE-----------ASDPTKQSKPME 291
            .|::::.|.||:|||.:..           ...||.:.:|.|
Human   260 EVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKE 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	112/212 (53%)
SIRT6	NP_057623.2	SIRT7	45..257	CDD:238701	112/212 (53%)
		Disordered. /evidence=ECO:0000269|PubMed:33067423	284..355		4/18 (22%)