Protein Alignment Sirt6 and SIRT7

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: XP_024306560.1
• Gene: SIRT7 / 51547
• HGNCID: 14935
• Length: 442
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 110/326 - (33%)
• Similarity: 149/326 - (45%)
• Gaps: 85/326 - (26%)

  Fly    22 ESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVS- 85
            |..|..|.:..|.:|||..::.:.::|::|||||||:|.|||:|||.|||||.:||.    :||
Human    77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGR----SVSA 137

  Fly    86 --FDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC--RR 146
              ..||.||.|||:|..|.|...||:|:|||.|||||:|||.|..:||||||:|||.|..|  .|
Human   138 ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNR 202

  Fly   147 QFVSPSAVETVGQKSLQRACKSSMDSKGRSC-RSGI-LYDNV------------LDWEHDLPEND 197
            ::|  ...:...:.:|.|      ...||:| :.|. |.|.:            |:|
Human   203 EYV--RVFDVTERTALHR------HQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNW-------- 251

  Fly   198 LEMGVMHSTVADLNIALGTTLQI-------VPSGDLPLKNLKCG--------------------- 234
             |.....::.||..:.||::|::       .||...|.....||
Human   252 -EAATEAASRADTILCLGSSLKVRADDTMSEPSPCPPEGVQLCGPALYRLVPCVCAVSVCLLPQV 315

  Fly   235 -----------------GKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLGVEIPEYSEASD 282
                             .|..|.|||.|..|..|.|.:....|.|:..:...||:|||.||...|
Human   316 LKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQD 380

  Fly   283 P 283
            |
Human   381 P 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	92/276 (33%)
SIRT7	XP_024306560.1	YscO	16..>101	CDD:284686	7/23 (30%)
		SIRT7	100..356	CDD:238701	92/276 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D468902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820