Protein Alignment Sirt6 and Sirt6

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001365873.1
• Gene: Sirt6 / 50721
• MGIID: 1354161
• Length: 334
• Species: Mus musculus
• Alignment Length: 329
• Identity: 152/329 - (46%)
• Similarity: 209/329 - (63%)
• Gaps: 7/329 - (2%)

  Fly     1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFR 65
            ||.|||.|||.|.:||..|.||.||..|.:..|..|||.|:.:|..||.||||||||::||||||
Mouse     1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLMWQSSSVVFHTGAGISTASGIPDFR 65

  Fly    66 GPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLS 130
            ||.||||:||:|..|.|:.:|:.|||:|||||::.|...|::.:::|||:||||::||..|..|:
Mouse    66 GPHGVWTMEERGLAPKFDTTFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLA 130

  Fly   131 ELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPE 195
            |||||:::|:|.||:.|:|..:.|.|:|.|:..|.|..:.....|:|| |.|.|.:||||..||:
Mouse   131 ELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKTRGLRACR-GELRDTILDWEDSLPD 194

  Fly   196 NDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVD 260
            .||.:....|..|||::.|||:|||.|||:|||...:.||:.||.||||||||::|:|.|..|||
Mouse   195 RDLMLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVD 259

  Fly   261 VVLSKVCKLLGVEIPEY------SEASDPTKQSKPMEWTIPTSNVNTFHRQYKKYVKDSKIESKA 319
            .|:.::.|.||:|||.:      .:|..|..:...::...|.......|..||.......:....
Mouse   260 EVMCRLMKHLGLEIPAWDGPCVLDKALPPLPRPVALKAEPPVHLNGAVHVSYKSKPNSPILHRPP 324

  Fly   320 KKTK 323
            |:.|
Mouse   325 KRVK 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	111/212 (52%)
Sirt6	NP_001365873.1	SIRT7	45..257	CDD:238701	111/211 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..334		2/12 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836235
Domainoid	1	1.000	138	1.000	Domainoid score	I4845
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6924
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2738
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54280
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006144
OrthoInspector	1	1.000	-	-		oto93214
orthoMCL	1	0.900	-	-		OOG6_104149
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4758
SonicParanoid	1	1.000	-	-		X4436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830