Protein Alignment Sirt6 and sirt6

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001002071.1
• Gene: sirt6 / 415161
• ZFINID: ZDB-GENE-031007-2
• Length: 354
• Species: Danio rerio
• Alignment Length: 330
• Identity: 163/330 - (49%)
• Similarity: 221/330 - (66%)
• Gaps: 22/330 - (6%)

  Fly     1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFR 65
            ||.|||.|||.|.:|||.|.||:|||.|.:..|.:.||:.|::|.::|:|:|||||||.||||||
Zfish     1 MSVNYAAGLSPYADKGICGLPETFDSPEELKTKVETLAQWIRESQYMVVHSGAGISTSTGIPDFR 65

  Fly    66 GPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLS 130
            ||.||||:||:||.|.||.:|::|||:.||||::.:..:|:::|:||||:||||::||..|..||
Zfish    66 GPNGVWTMEERGETPHFNTTFEDARPSLTHMALLQMQRTGHLKYLISQNVDGLHVRSGFPRDRLS 130

  Fly   131 ELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKG-RSCRSGILYDNVLDWEHDLP 194
            |||||:::|:|:||.:|:|..:.|..:|.|...|.| ..|.|:| |||| |.|..::||||..||
Zfish   131 ELHGNMFVEECEKCGKQYVRDTVVGVMGLKPTGRYC-DVMRSRGLRSCR-GKLISSILDWEDSLP 193

  Fly   195 ENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYV 259
            :.||......|..|||.:.|||:|||.|||||||...:.|||.||.|||||||||.|:|.|..||
Zfish   194 DRDLNRADEASRRADLALTLGTSLQIKPSGDLPLLTKRTGGKLVIVNLQPTKHDKHAHLRIYGYV 258

  Fly   260 DVVLSKVCKLLGVEIPEYSEASDPTKQSKPMEWTIPT----SNVNTFHRQYKKYVKDSKIESKAK 320
            |.|:.::.||||:::|               ||..||    |..:.....|..:.|:.|||.|.:
Zfish   259 DDVMGQLMKLLGLDVP---------------EWAGPTLCEDSGGDLDILPYGAWKKEVKIELKIE 308

  Fly   321 KTKYT 325
            ::.:|
Zfish   309 ESNHT 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	118/213 (55%)
sirt6	NP_001002071.1	SIRT7	46..257	CDD:238701	118/212 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579697
Domainoid	1	1.000	133	1.000	Domainoid score	I5037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6924
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2620
OMA	1	1.010	-	-		QHG54280
OrthoDB	1	1.010	-	-		D1503290at2759
OrthoFinder	1	1.000	-	-		FOG0006144
OrthoInspector	1	1.000	-	-		oto39045
orthoMCL	1	0.900	-	-		OOG6_104149
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4758
SonicParanoid	1	1.000	-	-		X4436
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940