Protein Alignment Sirt6 and Sirt2

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001386559.1
• Gene: Sirt2 / 361532
• RGDID: 621481
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 328
• Identity: 79/328 - (24%)
• Similarity: 120/328 - (36%)
• Gaps: 100/328 - (30%)

  Fly    31 AEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPK-GVWTLEEKGEKP----DFNVSF---- 86
            :|:|:          .|:...||||||||||||||.|. |::...||...|    .|.:|:
  Rat    73 SERCR----------RVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKH 127

  Fly    87 -------------DEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYI 138
                         .:.:||..|..|..|.|.|.:....:||||.|...:||:.:.|.|.||..|.
  Rat   128 PEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYT 192

  Fly   139 EQC--KKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMG 201
            ..|  ..|.:::......|.:         .|....|...|:: ::..:::.:..:||.......
  Rat   193 SHCVNTSCGKEYTMSWMKEKI---------FSEATPKCEKCQN-VVKPDIVFFGENLPPRFFSCM 247

  Fly   202 VMHSTVADLNIALGTTLQIVPSGDL----PLKNLKCGGKFVICNLQPTKH--------------- 247
            ....:..||.|.:||:||:.|...|    ||...:     ::.|.:.|..
  Rat   248 QSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPR-----LLINKEKTGQTDPFLGMMMGLGGGM 307

  Fly   248 ---DKKANLIISSYVDVVLSKVC--------KLLG---------------VEIPEYSEASDPTKQ 286
               .|||      |.||.....|        .|||               ::....|:||:|:..
  Rat   308 DFDSKKA------YRDVAWLGDCDQGCLALADLLGWKKELEDLVRREHANIDAQSGSQASNPSAT 366

  Fly   287 SKP 289
            ..|
  Rat   367 VSP 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	65/258 (25%)
Sirt2	NP_001386559.1	SIRT1	77..331	CDD:238699	69/284 (24%)