Protein Alignment Sirt6 and Sirt1

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 71/296 - (23%)
• Similarity: 125/296 - (42%)
• Gaps: 57/296 - (19%)

  Fly    14 NKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWT--LEEK 76
            ||  |.:..:||          ::..|:|||..:::.||||:|.|.||||||...|::.  ..:.
  Fly   203 NK--LASVNTFD----------DVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDF 255

  Fly    77 GEKPDFNVSFD---------------------EARPTKTHMAIIALIESGYVQYVISQNIDGLHL 120
            .:.||....||                     |.:|:..|..|..|...|.:....:||||.|..
  Fly   256 PDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLER 320

  Fly   121 KSGLDRKYLSELHGNIYIEQCKKCR---------------RQFVSPSAVETVGQKSLQRACKSSM 170
            .:|:.|  :.|.||:.....|.|||               |..|.|.. :...::|:..:...:.
  Fly   321 VAGIQR--VIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQC-QPNKEQSVDASVAVTE 382

  Fly   171 DSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGG 235
            :...:...:||:..:::.:...||:....:......|.||.|.:|::|::.|...:| .::....
  Fly   383 EELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIP-SSIPATV 446

  Fly   236 KFVICNLQPTKHDK-KANLIISSYVDVVLSKVCKLL 270
            ..::.|.:...|.| ...|:..|  ||:::::|..|
  Fly   447 PQILINREQLHHLKFDVELLGDS--DVIINQICHRL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	57/251 (23%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	60/259 (23%)