DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and sirt2

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_955890.1	Gene:	sirt2 / 322309	ZFINID:	ZDB-GENE-030131-1028	Length:	379	Species:	Danio rerio

Alignment Length:	362	Identity:	83/362 - (22%)
Similarity:	134/362 - (37%)	Gaps:	117/362 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGP-KGVWTLEEKGEKPDFNVSFDEA--- 89
            :::.||:          :::...||||||||||||||.| .|::...:|     :|:.:.||
Zfish    69 ILSGKCK----------NIICMVGAGISTSAGIPDFRSPGTGLYANLQK-----YNLPYPEAIFQ 118

  Fly    90 -----------------------RPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSE 131
                                   :||..|..|..|.:.|.::...|||||.|...:||:.:.|.|
Zfish   119 IDYFKKHPEPFFALARELYPGQFKPTVYHYFIKMLKDKGLLRRCYSQNIDTLERVAGLEGEDLIE 183

  Fly   132 LHGNIYIEQCKK--CRRQFVSPSAVETVGQKSLQRACKSSMD-----------SKGRSCRSGILY 183
            .||..:...|..  ||:::                    |||           .|..||.| ::.
Zfish   184 AHGTFHTSHCVSFLCRKEY--------------------SMDWMKNQIFSEEIPKCDSCGS-LVK 227

  Fly   184 DNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLK-NLKCGGKFVICNLQPTKH 247
            .:::.:...||..............||.|.:||:||:.|...|..: :.:|  ..::.|::.|..
Zfish   228 PDIVFFGESLPSRFFTSMKADFPQCDLLIIMGTSLQVQPFASLVSRVSNRC--PRLLINMEKTGQ 290

  Fly   248 DKKANLIIS-----------SYVDVVLSKVC--------KLLGVEIPEYSEASDPTKQSKPMEWT 293
            .:....:.|           :|.||.....|        :|||              ..|.:|..
Zfish   291 SEFGMGLFSFGGGMDFDSDKAYRDVAHLSTCDDGCMTLAELLG--------------WKKELEEM 341

  Fly   294 IPTSNVNTFHRQYKKYVKDSKIESK-----AKKTKYT 325
            :...:.....:..||..|::...||     |:||..|
Zfish   342 VKREHALIDSKDAKKTDKEASQSSKSAVAEAEKTDKT 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	63/264 (24%)
sirt2	NP_955890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		SIRT1	75..328	CDD:238699	67/290 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..379		9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54280
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820