DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and SIRT1

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_036370.2	Gene:	SIRT1 / 23411	HGNCID:	14929	Length:	747	Species:	Homo sapiens

Alignment Length:	281	Identity:	60/281 - (21%)
Similarity:	120/281 - (42%)	Gaps:	36/281 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWT--LEEKGEKPDFNVSFD---------- 87
            ::..:|:::...:::.||||:|.|.||||||...|::.  ..:..:.||....||
Human   244 EDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRP 308

  Fly    88 -----------EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQC 141
                       :.:|:..|..|....:.|.:....:||||.|...:|:.|  :.:.||:.....|
Human   309 FFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGSFATASC 371

  Fly   142 KKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHST 206
            ..|:.:....:....:..:.:.|..:...|..     ..|:...::.:..:|||...........
Human   372 LICKYKVDCEAVRGDIFNQVVPRCPRCPADEP-----LAIMKPEIVFFGENLPEQFHRAMKYDKD 431

  Fly   207 VADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLG 271
            ..||.|.:|::|::.|...:| .::......::.|.:|..| ...::.:....||:::::|..||
Human   432 EVDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH-LHFDVELLGDCDVIINELCHRLG 494

  Fly   272 VEIPEYSE-ASDPTKQSKPME 291
               .||:: ..:|.|.|:..|
Human   495 ---GEYAKLCCNPVKLSEITE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	48/235 (20%)
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135
		Interaction with H1-4. /evidence=ECO:0000269\|PubMed:15469825	2..268		6/23 (26%)
		Interaction with CLOCK. /evidence=ECO:0000250\|UniProtKB:Q923E4	2..139
		Nuclear localization signal. /evidence=ECO:0000250	32..39
		Nuclear export signal. /evidence=ECO:0000250	138..145
		Interaction with CCAR2	143..541		60/281 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230
		SIRT1	254..489	CDD:238699	50/243 (21%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269\|PubMed:25406032	256..259		0/2 (0%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..549
		Phosphorylated at one of three serine residues	538..540
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810