Protein Alignment Sirt6 and SIRT4

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001372662.1
• Gene: SIRT4 / 23409
• HGNCID: 14932
• Length: 314
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 72/284 - (25%)
• Similarity: 121/284 - (42%)
• Gaps: 81/284 - (28%)

  Fly    32 EKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPK-GVWTLEEKGEKP----DFNVS------ 85
            ||.:||...|..|..:::.|||||||.:||||:|..| |::...::  :|    ||..|
Human    42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDR--RPIQHGDFVRSAPIRQR 104

  Fly    86 -----------FDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIE 139
                       |...:|...|.|:....:.|.:.::::||:|.||.|:|..|  |:||||.:...
Human   105 YWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LTELHGCMDRV 167

  Fly   140 QCKKC-----------RRQFVSPS-AVETVG----------QKSLQRACKSSMDSKGRSCRSGIL 182
            .|..|           |.|.::|: :.|..|          ::.::.....:....|...:..::
Human   168 LCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVV 232

  Fly   183 Y--DNVLDWEHDLPENDLEMGVMHSTV--ADLNIALGTTLQIVPSG----------DLPLKNLKC 233
            :  |.|         |..::..:|..|  ||..:.:|::||:. ||          .||:
Human   233 FFGDTV---------NPDKVDFVHKRVKEADSLLVVGSSLQVY-SGYRFILTAWEKKLPI----- 282

  Fly   234 GGKFVICNLQPTKHDKKANLIISS 257
                .|.|:.||:.|..|.|.::|
Human   283 ----AILNIGPTRSDDLACLKLNS 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	66/271 (24%)
SIRT4	NP_001372662.1	SIRT4	47..308	CDD:238700	69/279 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810