Protein Alignment Sirt6 and SIRT5

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_036373.1
• Gene: SIRT5 / 23408
• HGNCID: 14933
• Length: 310
• Species: Homo sapiens
• Alignment Length: 238
• Identity: 62/238 - (26%)
• Similarity: 96/238 - (40%)
• Gaps: 57/238 - (23%)

  Fly    30 VAEKCQELAELIK---KSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDF--------N 83
            :|.....:|:..|   |:.|:|:.:|||:|..:|:|.|||..|.|   .|.:..|.        |
Human    33 MARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYW---RKWQAQDLATPLAFAHN 94

  Fly    84 VS------------FDEARPTKTHMAI----IALIESGYVQYVISQNIDGLHLKSGLDRKYLSEL 132
            .|            .....|...|.||    ..|.:.|....||:||||.||.|:|  .|.|.|:
Human    95 PSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG--TKNLLEI 157

  Fly   133 HGNIYIEQCKKC---RRQFVSPSAVETVGQ--------------KSLQRACKSSMDSKGRSCRSG 180
            ||:::..:|..|   ...:.||......|:              :.|.| |:.:      .| .|
Human   158 HGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPR-CEEA------GC-GG 214

  Fly   181 ILYDNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPS 223
            :|..:|:.:..:|....||.........||.:.:||:..:.|:
Human   215 LLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPA 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	58/220 (26%)
SIRT5	NP_036373.1	SIRT5_Af1_CobB	51..301	CDD:238703	58/220 (26%)