DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and SIRT2

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_036369.2	Gene:	SIRT2 / 22933	HGNCID:	10886	Length:	389	Species:	Homo sapiens

Alignment Length:	323	Identity:	75/323 - (23%)
Similarity:	119/323 - (36%)	Gaps:	84/323 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPK-GVWTLEEKGEKP----DFNVSF---- 86
            :|:|:          .|:...||||||||||||||.|. |::...||...|    .|.:|:
Human    73 SERCR----------RVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKH 127

  Fly    87 -------------DEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYI 138
                         .:.:||..|..:..|.:.|.:....:||||.|...:||:::.|.|.||..|.
Human   128 PEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYT 192

  Fly   139 EQC--KKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMG 201
            ..|  ..||.::......|.:         .|.:..|...|:| ::..:::.:...||.......
Human   193 SHCVSASCRHEYPLSWMKEKI---------FSEVTPKCEDCQS-LVKPDIVFFGESLPARFFSCM 247

  Fly   202 VMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLII----------- 255
            .......||.:.:||:||:.|...|..|......:.:|...:..:.|....:|:
Human   248 QSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSK 312

  Fly   256 SSYVDVVLSKVC--------KLL---------------------GVEIPEYSEASDPTKQSKP 289
            .:|.||.....|        :||                     |..:|..|.::.|.|...|
Human   313 KAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	61/247 (25%)
SIRT2	NP_036369.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Nuclear export signal	41..51
		SIRT1	77..331	CDD:238699	65/273 (24%)
		Peptide inhibitor binding	116..120		0/3 (0%)
		Peptide inhibitor binding	232..301		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..389		6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54280
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820