DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and Sirt7

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_694696.2	Gene:	Sirt7 / 209011	MGIID:	2385849	Length:	402	Species:	Mus musculus

Alignment Length:	289	Identity:	106/289 - (36%)
Similarity:	146/289 - (50%)	Gaps:	53/289 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVSF 86
            |..|..|.:..|.:|||..::.:.|:|::|||||||:|.|||:|||.|||||.:|| :|......
Mouse    78 EVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKG-RPVSAADL 141

  Fly    87 DEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC--RRQFV 149
            .||.||.|||:|..|.|...||:|:|||.|||||:|||.|..:||||||:|||.|..|  .|::|
Mouse   142 SEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYV 206

  Fly   150 SPSAVETVGQKSLQRACKSSMDSKGRSC-RSGI-LYDNV------------LDWEHDLPENDLEM 200
              ...:...:.:|.|      ...||:| :.|. |.|.:            |:|         |.
Mouse   207 --RVFDVTERTALHR------HLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNW---------EA 254

  Fly   201 GVMHSTVADLNIALGTTLQIV-----------PSGDLPLKNLKCGGKFVICNLQPTKHDKKANLI 254
            ....::.||..:.||::|:::           |....|        |..|.|||.|..|..|.|.
Mouse   255 ATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRP--------KLYIVNLQWTPKDDWAALK 311

  Fly   255 ISSYVDVVLSKVCKLLGVEIPEYSEASDP 283
            :....|.|:..:...||:|||.|:...||
Mouse   312 LHGKCDDVMQLLMNELGLEIPVYNRWQDP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	89/239 (37%)
Sirt7	NP_694696.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SIRT7	102..315	CDD:238701	89/238 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..402
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D468902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820