Protein Alignment Sirt6 and Sirt7

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_694696.2
• Gene: Sirt7 / 209011
• MGIID: 2385849
• Length: 402
• Species: Mus musculus
• Alignment Length: 289
• Identity: 106/289 - (36%)
• Similarity: 146/289 - (50%)
• Gaps: 53/289 - (18%)

  Fly    22 ESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVSF 86
            |..|..|.:..|.:|||..::.:.|:|::|||||||:|.|||:|||.|||||.:|| :|......
Mouse    78 EVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKG-RPVSAADL 141

  Fly    87 DEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC--RRQFV 149
            .||.||.|||:|..|.|...||:|:|||.|||||:|||.|..:||||||:|||.|..|  .|::|
Mouse   142 SEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYV 206

  Fly   150 SPSAVETVGQKSLQRACKSSMDSKGRSC-RSGI-LYDNV------------LDWEHDLPENDLEM 200
              ...:...:.:|.|      ...||:| :.|. |.|.:            |:|         |.
Mouse   207 --RVFDVTERTALHR------HLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNW---------EA 254

  Fly   201 GVMHSTVADLNIALGTTLQIV-----------PSGDLPLKNLKCGGKFVICNLQPTKHDKKANLI 254
            ....::.||..:.||::|:::           |....|        |..|.|||.|..|..|.|.
Mouse   255 ATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRP--------KLYIVNLQWTPKDDWAALK 311

  Fly   255 ISSYVDVVLSKVCKLLGVEIPEYSEASDP 283
            :....|.|:..:...||:|||.|:...||
Mouse   312 LHGKCDDVMQLLMNELGLEIPVYNRWQDP 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	89/239 (37%)
Sirt7	NP_694696.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		DUF5401	<11..>91	CDD:375164	4/12 (33%)
		SIRT7	102..315	CDD:238701	89/238 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..402