Protein Alignment Sirt6 and sir-2.3

DIOPT Version :10

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_510220.1
• Gene: sir-2.3 / 185876
• WormBaseID: WBGene00004802
• Length: 287
• Species: Caenorhabditis elegans
• Alignment Length: 285
• Identity: 75/285 - (26%)
• Similarity: 123/285 - (43%)
• Gaps: 54/285 - (18%)

  Fly    28 EVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKP----DFNVS--- 85
            |:.....::...|:.....:::.|||||||.:||||:|. |.|....:...:|    ||..|
 Worm    11 ELCENSLKKFKSLVGTVDKLLIITGAGISTESGIPDYRS-KDVGLYTKTALEPIYFQDFMKSKKC 74

  Fly    86 --------------FDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNI 136
                          |.:|.|...|.|:.....:....::|:||:||||||:|  .|.::|||||.
 Worm    75 RQRYWSRSYLNWPRFAQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAG--SKMITELHGNA 137

  Fly   137 YIEQCKKC--------------------RRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRS-- 179
            ...:|..|                    :.|||||...|.....:|...  |....|...|.:
 Worm   138 LQVKCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLG--SEQGFKIPECLNCG 200

  Fly   180 GILYDNVLDWEHDLPENDLEMGVMHSTVADLN--IALGTTLQIVPSGDLPLKNLKCGGK-FVICN 241
            |::..:|..:..:|  |..::.|....|.:.|  :.|||:|::: ||...:.:.....| ..|.|
 Worm   201 GLMKTDVTLFGENL--NTDKIKVCGKKVNECNGVLTLGTSLEVL-SGYQIVNHAHMQNKPIFIVN 262

  Fly   242 LQPTKHDKKANLIISSYVDVVLSKV 266
            :.||:.|:.|.:.:...:..||.::
 Worm   263 IGPTRADQMATMKLDYRISDVLKEM 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	71/258 (28%)
sir-2.3	NP_510220.1	SIRT4	20..284	CDD:238700	72/271 (27%)