Protein Alignment Sirt6 and sir-2.4

DIOPT Version :9

• Sequence 1: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_491733.2
• Gene: sir-2.4 / 182284
• WormBaseID: WBGene00004803
• Length: 292
• Species: Caenorhabditis elegans
• Alignment Length: 278
• Identity: 101/278 - (36%)
• Similarity: 159/278 - (57%)
• Gaps: 7/278 - (2%)

  Fly     1 MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAE---LIKKSGH-VVLHTGAGISTSAGI 61
            |:..|...||.|.:||::|.||..|::..:.||.:.|..   ..|::|. :.:..|||:||.:.:
 Worm     1 MTSVYESLLSDYPDKGVIGKPEIRDTETEIIEKLRTLYNHFVQAKQTGKPIFVLIGAGVSTGSKL 65

  Fly    62 PDFRGPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDR 126
            |||||.:|||||:.:|:..: .|.|..|||..:|.:|:||.::||::.:|:||:|||..|.|:..
 Worm    66 PDFRGKQGVWTLQAEGKHAE-GVDFQVARPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPV 129

  Fly   127 KYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEH 191
            :.|.|:|||:::|.|:.|..::|....|.:||.....|.|:.:..: ||||| |.|.|..|||:.
 Worm   130 EDLIEVHGNLFLEVCQSCFSEYVREEIVMSVGLCPTGRNCEGNKRT-GRSCR-GKLRDATLDWDT 192

  Fly   192 DLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIIS 256
            ::..|.|:............:.:||:|:|:|.|.|||.....|.|....|.|.|.|:|.....|.
 Worm   193 EISLNHLDRIRKAWKQTSHLLCIGTSLEIIPMGSLPLDAKSKGIKTTTINYQETAHEKIVETAIH 257

  Fly   257 SYVDVVLSKVCKLLGVEI 274
            :.|.::|..:|..|||.:
 Worm   258 ADVKLILYSLCNALGVNV 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	80/213 (38%)
sir-2.4	NP_491733.2	SIR2	49..259	CDD:294129	79/212 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158847
Domainoid	1	1.000	91	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I2726
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54280
OrthoDB	1	1.010	-	-		D1503290at2759
OrthoFinder	1	1.000	-	-		FOG0006144
OrthoInspector	1	1.000	-	-		oto19111
orthoMCL	1	0.900	-	-		OOG6_104149
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4758
SonicParanoid	1	1.000	-	-		X4436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800