DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt6 and sirt1

DIOPT Version :9

Sequence 1:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	XP_012821550.2	Gene:	sirt1 / 100145679	XenbaseID:	XB-GENE-989003	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	303	Identity:	64/303 - (21%)
Similarity:	136/303 - (44%)	Gaps:	49/303 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELAELIKKSGHVVLHTGAGISTSAGIPDFR-----------------GPKGVWTLE--EKGEKPD 81
            :..:|:::|..:::.||||:|.|.||||||                 .|:.::.:|  .|..:|.
Frog   285 DAVKLLQESKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPNPQAMFDIEYFRKDPRPF 349

  Fly    82 FNVSFD----EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCK 142
            |..:.:    :.:|:..|..|..|.:...:....:||||.|...:|:::  :.:.||:.....|.
Frog   350 FKFAKEIFPGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEK--IIQCHGSFAEASCL 412

  Fly   143 KCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHSTV 207
            .|:.:....:..|.:..:.:.|..:.|.|..     ..|:..:::.:..:|||............
Frog   413 VCKYKVDCEAVREDIFNQIVPRCPRCSSDEP-----LAIMKPDIVFFGENLPEQFHRAMKYDKNE 472

  Fly   208 ADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLGV 272
            .||.|.:|::|::.|...:| .::......::.|.:|..| ...::.:....||:::::|:.|.
Frog   473 VDLLIVIGSSLKVRPVALIP-SSIPHEVPQILINREPLPH-LHFDIELLGDCDVIINELCQRLD- 534

  Fly   273 EIPEYSE-ASDPTKQSKPME-------------WTIPTSNVNT 301
              .:||: .::..|.|:..|             .|:|::::||
Frog   535 --GKYSQLCTNSLKLSQITEKPPRIHKGFLTSPETVPSTDLNT 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	49/235 (21%)
sirt1	XP_012821550.2	SIRT1	294..529	CDD:238699	51/243 (21%)
sirt1	XP_012821550.2	MSCRAMM_ClfB	<593..753	CDD:411414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910