DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3999 and GLDP2

DIOPT Version :9

Sequence 1:	NP_001262456.1	Gene:	CG3999 / 41253	FlyBaseID:	FBgn0037801	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_180178.1	Gene:	GLDP2 / 817149	AraportID:	AT2G26080	Length:	1044	Species:	Arabidopsis thaliana

Alignment Length:	994	Identity:	544/994 - (54%)
Similarity:	696/994 - (70%)	Gaps:	26/994 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FLGRS---SQSLLLRCGHRYLATTPVEEVIFPTKSDFPSRHIGPRKTDVVAMLDTLGFKSLAELT 65
            ||.|.   |.|.....|.....|..:..........||.||......:...|.:..||.:|..|.
plant    48 FLHRRRDVSGSAFTTSGRNQHQTRSISVDALKPSDTFPRRHNSATPDEQAQMANYCGFDNLNTLI 112

  Fly    66 EKAVPQSIQL---KRELDLDKPLNEHELIRRIRDISLKNQLWRSYIGMGYHNCHVPHTIIRNMFE 127
            :..||:||:|   |.....|:.|.|.::|..:.|::.||::::|:|||||:|.|||..|:||:.|
plant   113 DSTVPKSIRLDSMKFSGIFDEGLTESQMIEHMSDLASKNKVFKSFIGMGYYNTHVPPVILRNIME 177

  Fly   128 NPGWTTQYTPYQPEIAQGRLESLLNYQTLVTDLTGLDVANASLLDEGTAAAEAMCLATR--HNKR 190
            ||.|.|||||||.||:||||||||||||::||||||.::|||||||||||||||.:...  ..|:
plant   178 NPAWYTQYTPYQAEISQGRLESLLNYQTVITDLTGLPMSNASLLDEGTAAAEAMAMCNNILKGKK 242

  Fly   191 KKLYLSNRVHPQTLSVVKTRTEALELEIVVGPIEQADLPSRELAGILLQYPDTYGDVKDFEDIAA 255
            |...:::..||||:.|.|||.:..:|::|...|:..|..|.::.|:|:|||.|.|:|.|:.:...
plant   243 KTFVIASNCHPQTIDVCKTRADGFDLKVVTVDIKDVDYSSGDVCGVLVQYPGTEGEVLDYGEFVK 307

  Fly   256 LAKKNGTLVVVATDLLSLTLLRPPAEFGADIAVGTSQRLGVPLGYGGPHAGFFACKQSLVRLMPG 320
            .|..||..||:|||||:||:|:||.||||||.||:.||.|||:|||||||.|.|..|...|:|||
plant   308 NAHANGVKVVMATDLLALTMLKPPGEFGADIVVGSGQRFGVPMGYGGPHAAFLATSQEYKRMMPG 372

  Fly   321 RMIGVTRDMDGNDAYRLALQTREQHIRRDKATSNICTAQALLANMSAMYAIYHGPEGLKAMANRI 385
            |:|||:.|..|..|.|:|:||||||||||||||||||||||||||:||||:||||||||::|.|:
plant   373 RIIGVSVDSSGKQALRMAMQTREQHIRRDKATSNICTAQALLANMTAMYAVYHGPEGLKSIAQRV 437

  Fly   386 HHFTLTLQTGV--LGAGHEVINKNFFDTLHIRLGGGQSLEDLKERAEHKRINLRYLEDDTVGVAL 448
            |........|:  ||.. :|.:..||||:.:......::.|:   |..|.||||.::.:|:.||.
plant   438 HGLAGVFALGLKKLGTA-QVQDLPFFDTVKVTCSDATAIFDV---AAKKEINLRLVDSNTITVAF 498

  Fly   449 DETVSVADVDDLLWVFKAEASVE---HILARKDVLKNSIENSKFLRTSPYLQHPIFQSYHSESRM 510
            |||.::.|||.|..||.:...|:   ..||.:  ..|:|.:| ..|.||||.||||..||:|..:
plant   499 DETTTLDDVDKLFEVFASGKPVQFTAESLAPE--FNNAIPSS-LTRESPYLTHPIFNMYHTEHEL 560

  Fly   511 VRYMKKLENKDISLVHSMIPLGSCTMKLNSTTEMMPCSFRHFTDIHPFAPVEQAQGFHQMFKELE 575
            :||:.||:|||:||.||||||||||||||:||||||.::..||::|||||||||||:.:||..|.
plant   561 LRYIHKLQNKDLSLCHSMIPLGSCTMKLNATTEMMPVTWPSFTNMHPFAPVEQAQGYQEMFTNLG 625

  Fly   576 HDLCEITGYDRISFQPNSGAQGEYAGLRAIRSYHEHRNEGHRNICLIPISAHGTNPASAQMAGMK 640
            ..||.|||:|..|.|||:||.||||||..||:||..|.:.|||:|:||:||||||||||.|.|||
plant   626 ELLCTITGFDSFSLQPNAGAAGEYAGLMVIRAYHMSRGDHHRNVCIIPVSAHGTNPASAAMCGMK 690

  Fly   641 VEPIRILSNGSIDMAHLRAKAEEHAHELSCLMITYPSTMGVFEETVADICTLIHKHGGQVYLDGA 705
            :..:...:.|:|::..||..||.:...|:.||:|||||.||:||.:.:||.:||::|||||:|||
plant   691 IVAVGTDAKGNINIEELRNAAEANKDNLAALMVTYPSTHGVYEEGIDEICNIIHENGGQVYMDGA 755

  Fly   706 NMNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPYLPGHPVVS----PLS 766
            ||||||||..||..|:||.|||||||||||||||||||||||||.||||:||.|||:.    |..
plant   756 NMNAQVGLTSPGFIGADVCHLNLHKTFCIPHGGGGPGMGPIGVKQHLAPFLPSHPVIPTGGIPEP 820

  Fly   767 SEEHSFGVVSAAPFGSSAILPISWSYIKLMGSRGLKRATQVAILNANYMSKRLEQHYKTLYKAPN 831
            .:....|.:||||:||:.|||||::||.:|||.||..|:::||||||||:||||.||..|::..|
plant   821 EQTSPLGTISAAPWGSALILPISYTYIAMMGSGGLTDASKIAILNANYMAKRLESHYPVLFRGVN 885

  Fly   832 SQLVAHEFILDIRDLKKSANIEAVDVAKRLMDYGFHAPTMSWPVAGTLMIEPTESEDKEELDRFC 896
            . .||||||:|:|..|.:|.||..||||||||||||.|||||||.|||||||||||.|.||||||
plant   886 G-TVAHEFIIDLRGFKNTAGIEPEDVAKRLMDYGFHGPTMSWPVPGTLMIEPTESESKAELDRFC 949

  Fly   897 DAMISIREEIAEIEAGRMDKAVNPLKMSPHTQAQVISDKWDRPYTREQAAFPAIFVKPDAKIWPT 961
            ||:|||||||::||.|..|...|.||.:||..:.:::|.|.:||:||.|||||.::: .:|.|||
plant   950 DALISIREEISQIEKGNADPNNNVLKGAPHPPSLLMADTWKKPYSREYAAFPAPWLR-SSKFWPT 1013

  Fly   962 VGRIDDAYGDKHLVCTCPP 980
            .||:|:.|||::||||..|
plant  1014 TGRVDNVYGDRNLVCTLQP 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3999	NP_001262456.1	PRK05367	35..981	CDD:235432	537/960 (56%)
		GDC-P	40..464	CDD:280502	220/430 (51%)
		GcvP2	494..949	CDD:223935	288/458 (63%)
GLDP2	NP_180178.1	PLN02414	1..1044	CDD:178035	544/994 (55%)
		GDC-P	86..514	CDD:280502	220/431 (51%)
		GcvP2	524..1009	CDD:223935	297/489 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	427	1.000	Domainoid score	I111
eggNOG	1	0.900	-	-		E1_COG1003
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H141
Inparanoid	1	1.050	1060	1.000	Inparanoid score	I35
OMA	1	1.010	-	-		QHG62689
OrthoDB	1	1.010	-	-		D390348at2759
OrthoFinder	1	1.000	-	-		FOG0002904
OrthoInspector	1	1.000	-	-		otm2486
orthoMCL	1	0.900	-	-		OOG6_101195
Panther	1	1.100	-	-	O	PTHR11773
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840