DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3999 and GLDC

DIOPT Version :9

Sequence 1:	NP_001262456.1	Gene:	CG3999 / 41253	FlyBaseID:	FBgn0037801	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_000161.2	Gene:	GLDC / 2731	HGNCID:	4313	Length:	1020	Species:	Homo sapiens

Alignment Length:	959	Identity:	618/959 - (64%)
Similarity:	755/959 - (78%)	Gaps:	12/959 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EVIFPTKSDFPSRHIGPRKTDVVAMLDTLGFKSLAELTEKAVPQSIQLKRELDLDKPLNEHELIR 92
            |.:.|...||..|||||...|...||.|||..|:.||.||.||.:|:|||.|.::.|:.|:|::.
Human    54 ERLLPRHDDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILA 118

  Fly    93 RIRDISLKNQLWRSYIGMGYHNCHVPHTIIRNMFENPGWTTQYTPYQPEIAQGRLESLLNYQTLV 157
            .:..||.|||:|||||||||:||.||.||:||:.||.||.|||||||||::||||||||||||:|
Human   119 TLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMV 183

  Fly   158 TDLTGLDVANASLLDEGTAAAEAMCLATRHNKRKKLYLSNRVHPQTLSVVKTRTE----ALELEI 218
            .|:||||:|||||||||||||||:.|..|||||:|..:..|.||||::||:||.:    ..||::
Human   184 CDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKL 248

  Fly   219 VVGPIEQADLPSRELAGILLQYPDTYGDVKDFEDIAALAKKNGTLVVVATDLLSLTLLRPPAEFG 283
               |.|. |...::::|:|.|||||.|.|:||.::...|.::|:|...|||||:|.:||||.|||
Human   249 ---PCEM-DFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFG 309

  Fly   284 ADIAVGTSQRLGVPLGYGGPHAGFFACKQSLVRLMPGRMIGVTRDMDGNDAYRLALQTREQHIRR 348
            .|||:|:|||.|||||||||||.|||.::||||:|||||:|||||..|.:.||||||||||||||
Human   310 VDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRR 374

  Fly   349 DKATSNICTAQALLANMSAMYAIYHGPEGLKAMANRIHHFTLTLQTGVLGAGHEVINKNFFDTLH 413
            |||||||||||||||||:||:|||||..||:.:|.|:|:.||.|..|:..|||::.:..|||||.
Human   375 DKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLK 439

  Fly   414 IRLGGGQSLEDLKERAEHKRINLRYLEDDTVGVALDETVSVADVDDLLWVFKAEASVEHILARKD 478
            |:.  |.|::::..||..::||.|..||.|:|::|||||:..|:|||||:|..|:|.|.:.....
Human   440 IQC--GCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMG 502

  Fly   479 VLKNSIENSKFLRTSPYLQHPIFQSYHSESRMVRYMKKLENKDISLVHSMIPLGSCTMKLNSTTE 543
            .....|..|.|.||||:|.|.:|.|||||:.:||||||||||||||||||||||||||||||::|
Human   503 EECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSE 567

  Fly   544 MMPCSFRHFTDIHPFAPVEQAQGFHQMFKELEHDLCEITGYDRISFQPNSGAQGEYAGLRAIRSY 608
            :.|.:::.|.:||||.|::||||:.|:|:|||.||||:||||::.||||||||||||||..||:|
Human   568 LAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAY 632

  Fly   609 HEHRNEGHRNICLIPISAHGTNPASAQMAGMKVEPIRILSNGSIDMAHLRAKAEEHAHELSCLMI 673
            ...:.||||.:||||.||||||||||.|||||::|:.:...|:||..||:|..::|...|:.:||
Human   633 LNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMI 697

  Fly   674 TYPSTMGVFEETVADICTLIHKHGGQVYLDGANMNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGG 738
            |||||.|||||.::|:|.|||:|||||||||||||||||:|||||:|||||||||||||||||||
Human   698 TYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGG 762

  Fly   739 GGPGMGPIGVKAHLAPYLPGHPVVSPLSSEEH-SFGVVSAAPFGSSAILPISWSYIKLMGSRGLK 802
            |||||||||||.||||:||.|||:|...:|:. ..|.|||||:|||:||||||:|||:||.:|||
Human   763 GGPGMGPIGVKKHLAPFLPNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLK 827

  Fly   803 RATQVAILNANYMSKRLEQHYKTLYKAPNSQLVAHEFILDIRDLKKSANIEAVDVAKRLMDYGFH 867
            :||:.||||||||:||||.||:.|::.... .|.||||||.|..|||||||||||||||.|||||
Human   828 QATETAILNANYMAKRLETHYRILFRGARG-YVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFH 891

  Fly   868 APTMSWPVAGTLMIEPTESEDKEELDRFCDAMISIREEIAEIEAGRMDKAVNPLKMSPHTQAQVI 932
            |||||||||||||:||||||||.|||||||||||||:|||:||.||:|..|||||||||:...|.
Human   892 APTMSWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVT 956

  Fly   933 SDKWDRPYTREQAAFPAIFVKPDAKIWPTVGRIDDAYGDKHLVCTCPPI 981
            |..|||||:||.||||..||||:.|.|||:.||||.|||:||||||||:
Human   957 SSHWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPM 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3999	NP_001262456.1	PRK05367	35..981	CDD:235432	615/950 (65%)
		GDC-P	40..464	CDD:280502	256/427 (60%)
		GcvP2	494..949	CDD:223935	324/455 (71%)
GLDC	NP_000161.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..46
GLDC	NP_000161.2	PRK05367	57..1009	CDD:235432	617/956 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155491
Domainoid	1	1.000	515	1.000	Domainoid score	I312
eggNOG	1	0.900	-	-		E1_COG1003
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H141
Inparanoid	1	1.050	1276	1.000	Inparanoid score	I167
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62689
OrthoDB	1	1.010	-	-		D390348at2759
OrthoFinder	1	1.000	-	-		FOG0002904
OrthoInspector	1	1.000	-	-		oto90925
orthoMCL	1	0.900	-	-		OOG6_101195
Panther	1	1.100	-	-	LDO	PTHR11773
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R482
SonicParanoid	1	1.000	-	-		X2723
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800