Protein Alignment CG3999 and GLDC

DIOPT Version :10

• Sequence 1: NP_649989.1
• Gene: CG3999 / 41253
• FlyBaseID: FBgn0037801
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_000161.2
• Gene: GLDC / 2731
• HGNCID: 4313
• Length: 1020
• Species: Homo sapiens
• Alignment Length: 959
• Identity: 618/959 - (64%)
• Similarity: 755/959 - (78%)
• Gaps: 12/959 - (1%)

  Fly    28 EVIFPTKSDFPSRHIGPRKTDVVAMLDTLGFKSLAELTEKAVPQSIQLKRELDLDKPLNEHELIR 92
            |.:.|...||..|||||...|...||.|||..|:.||.||.||.:|:|||.|.::.|:.|:|::.
Human    54 ERLLPRHDDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILA 118

  Fly    93 RIRDISLKNQLWRSYIGMGYHNCHVPHTIIRNMFENPGWTTQYTPYQPEIAQGRLESLLNYQTLV 157
            .:..||.|||:|||||||||:||.||.||:||:.||.||.|||||||||::||||||||||||:|
Human   119 TLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMV 183

  Fly   158 TDLTGLDVANASLLDEGTAAAEAMCLATRHNKRKKLYLSNRVHPQTLSVVKTRTE----ALELEI 218
            .|:||||:|||||||||||||||:.|..|||||:|..:..|.||||::||:||.:    ..||::
Human   184 CDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKL 248

  Fly   219 VVGPIEQADLPSRELAGILLQYPDTYGDVKDFEDIAALAKKNGTLVVVATDLLSLTLLRPPAEFG 283
               |.|. |...::::|:|.|||||.|.|:||.::...|.::|:|...|||||:|.:||||.|||
Human   249 ---PCEM-DFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFG 309

  Fly   284 ADIAVGTSQRLGVPLGYGGPHAGFFACKQSLVRLMPGRMIGVTRDMDGNDAYRLALQTREQHIRR 348
            .|||:|:|||.|||||||||||.|||.::||||:|||||:|||||..|.:.||||||||||||||
Human   310 VDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRR 374

  Fly   349 DKATSNICTAQALLANMSAMYAIYHGPEGLKAMANRIHHFTLTLQTGVLGAGHEVINKNFFDTLH 413
            |||||||||||||||||:||:|||||..||:.:|.|:|:.||.|..|:..|||::.:..|||||.
Human   375 DKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLK 439

  Fly   414 IRLGGGQSLEDLKERAEHKRINLRYLEDDTVGVALDETVSVADVDDLLWVFKAEASVEHILARKD 478
            |:.  |.|::::..||..::||.|..||.|:|::|||||:..|:|||||:|..|:|.|.:.....
Human   440 IQC--GCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMG 502

  Fly   479 VLKNSIENSKFLRTSPYLQHPIFQSYHSESRMVRYMKKLENKDISLVHSMIPLGSCTMKLNSTTE 543
            .....|..|.|.||||:|.|.:|.|||||:.:||||||||||||||||||||||||||||||::|
Human   503 EECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSE 567

  Fly   544 MMPCSFRHFTDIHPFAPVEQAQGFHQMFKELEHDLCEITGYDRISFQPNSGAQGEYAGLRAIRSY 608
            :.|.:::.|.:||||.|::||||:.|:|:|||.||||:||||::.||||||||||||||..||:|
Human   568 LAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAY 632

  Fly   609 HEHRNEGHRNICLIPISAHGTNPASAQMAGMKVEPIRILSNGSIDMAHLRAKAEEHAHELSCLMI 673
            ...:.||||.:||||.||||||||||.|||||::|:.:...|:||..||:|..::|...|:.:||
Human   633 LNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMI 697

  Fly   674 TYPSTMGVFEETVADICTLIHKHGGQVYLDGANMNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGG 738
            |||||.|||||.::|:|.|||:|||||||||||||||||:|||||:|||||||||||||||||||
Human   698 TYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGG 762

  Fly   739 GGPGMGPIGVKAHLAPYLPGHPVVSPLSSEEH-SFGVVSAAPFGSSAILPISWSYIKLMGSRGLK 802
            |||||||||||.||||:||.|||:|...:|:. ..|.|||||:|||:||||||:|||:||.:|||
Human   763 GGPGMGPIGVKKHLAPFLPNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLK 827

  Fly   803 RATQVAILNANYMSKRLEQHYKTLYKAPNSQLVAHEFILDIRDLKKSANIEAVDVAKRLMDYGFH 867
            :||:.||||||||:||||.||:.|::.... .|.||||||.|..|||||||||||||||.|||||
Human   828 QATETAILNANYMAKRLETHYRILFRGARG-YVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFH 891

  Fly   868 APTMSWPVAGTLMIEPTESEDKEELDRFCDAMISIREEIAEIEAGRMDKAVNPLKMSPHTQAQVI 932
            |||||||||||||:||||||||.|||||||||||||:|||:||.||:|..|||||||||:...|.
Human   892 APTMSWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVT 956

  Fly   933 SDKWDRPYTREQAAFPAIFVKPDAKIWPTVGRIDDAYGDKHLVCTCPPI 981
            |..|||||:||.||||..||||:.|.|||:.||||.|||:||||||||:
Human   957 SSHWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPM 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3999	NP_649989.1	PLN02414	1..980	CDD:178035	616/956 (64%)
GLDC	NP_000161.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..46
		PLN02414	51..1009	CDD:178035	618/959 (64%)