DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3999 and Gldc

DIOPT Version :9

Sequence 1:	NP_001262456.1	Gene:	CG3999 / 41253	FlyBaseID:	FBgn0037801	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_613061.1	Gene:	Gldc / 104174	MGIID:	1341155	Length:	1025	Species:	Mus musculus

Alignment Length:	959	Identity:	619/959 - (64%)
Similarity:	757/959 - (78%)	Gaps:	12/959 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EVIFPTKSDFPSRHIGPRKTDVVAMLDTLGFKSLAELTEKAVPQSIQLKRELDLDKPLNEHELIR 92
            |.:.|...||..|||||...|...||..||..|:.||.||.||.||:|||.|.::.|:.|:|::.
Mouse    59 ERLLPRHDDFSRRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKMEDPICENEILE 123

  Fly    93 RIRDISLKNQLWRSYIGMGYHNCHVPHTIIRNMFENPGWTTQYTPYQPEIAQGRLESLLNYQTLV 157
            .:..|:.|||:|||||||||:||.||.||:||:.||.||.|||||||||::||||||||||||:|
Mouse   124 TLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMV 188

  Fly   158 TDLTGLDVANASLLDEGTAAAEAMCLATRHNKRKKLYLSNRVHPQTLSVVKTRTE----ALELEI 218
            :|:||||:||||||||.|||||||.|..|||||||.::..|.||||::||:||.:    .:||::
Mouse   189 SDITGLDMANASLLDEATAAAEAMQLCHRHNKRKKFFVDPRCHPQTIAVVQTRAKYRGVLVELKL 253

  Fly   219 VVGPIEQADLPSRELAGILLQYPDTYGDVKDFEDIAALAKKNGTLVVVATDLLSLTLLRPPAEFG 283
               |.|. |...:::.|:|.|||||.|.|:||.::...|.:.|:|...|||||:|.:||||.|||
Mouse   254 ---PHEM-DFSGKDVCGVLFQYPDTEGKVEDFTELVDRAHQTGSLTCCATDLLALCILRPPGEFG 314

  Fly   284 ADIAVGTSQRLGVPLGYGGPHAGFFACKQSLVRLMPGRMIGVTRDMDGNDAYRLALQTREQHIRR 348
            .|||:|.|||.|||||||||||.|||.|::|||:|||||:|||||..|.:.||||||||||||||
Mouse   315 VDIALGNSQRFGVPLGYGGPHAAFFAVKENLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRR 379

  Fly   349 DKATSNICTAQALLANMSAMYAIYHGPEGLKAMANRIHHFTLTLQTGVLGAGHEVINKNFFDTLH 413
            |||||||||||||||||:||:|||||.:|||.:|.|:|:.||.|..|:..|||::.:..|||||.
Mouse   380 DKATSNICTAQALLANMAAMFAIYHGSQGLKHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLK 444

  Fly   414 IRLGGGQSLEDLKERAEHKRINLRYLEDDTVGVALDETVSVADVDDLLWVFKAEASVEHILARKD 478
            ::.  |.|::::..||..::||.|..:|.|:|::|||||:..|:|||||:|..|:|.|.:.....
Mouse   445 VQC--GCSVKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSAELVAEGMG 507

  Fly   479 VLKNSIENSKFLRTSPYLQHPIFQSYHSESRMVRYMKKLENKDISLVHSMIPLGSCTMKLNSTTE 543
            ..:..:..|.|.||||:|.|.:|.|||||:.:||||||||||||||||||||||||||||||::|
Mouse   508 EERRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSE 572

  Fly   544 MMPCSFRHFTDIHPFAPVEQAQGFHQMFKELEHDLCEITGYDRISFQPNSGAQGEYAGLRAIRSY 608
            :.|.::|.|.:||||.|::||||:.|:|:.||.||||||||||:|||||||||||||||..||:|
Mouse   573 LAPITWREFANIHPFVPLDQAQGYQQLFQGLEKDLCEITGYDRVSFQPNSGAQGEYAGLATIRAY 637

  Fly   609 HEHRNEGHRNICLIPISAHGTNPASAQMAGMKVEPIRILSNGSIDMAHLRAKAEEHAHELSCLMI 673
            .:.:.|.||.:||||.||||||||||.|||||::|:.:...|:||:|||:|..::|...|:.:||
Mouse   638 LDQKGERHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDRYGNIDVAHLKAMVDQHKENLAAIMI 702

  Fly   674 TYPSTMGVFEETVADICTLIHKHGGQVYLDGANMNAQVGLCRPGDYGSDVSHLNLHKTFCIPHGG 738
            |||||.|||||.:.|:|.|||:|||||||||||||||||:|||||:|||||||||||||||||||
Mouse   703 TYPSTNGVFEENIGDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGG 767

  Fly   739 GGPGMGPIGVKAHLAPYLPGHPVVSPLSSE-EHSFGVVSAAPFGSSAILPISWSYIKLMGSRGLK 802
            |||||||||||.||:|:||.|||:|...:| ....|.|||||:|||:||||||:|||:||.:|||
Mouse   768 GGPGMGPIGVKKHLSPFLPSHPVISIKPTEGTWPVGTVSAAPWGSSSILPISWAYIKMMGGKGLK 832

  Fly   803 RATQVAILNANYMSKRLEQHYKTLYKAPNSQLVAHEFILDIRDLKKSANIEAVDVAKRLMDYGFH 867
            .||::||||||||:||||:||:.|::.... .||||||||.|..|||||:|||||||||.|||||
Mouse   833 EATEIAILNANYMAKRLEKHYRVLFRGARG-YVAHEFILDTRPFKKSANVEAVDVAKRLQDYGFH 896

  Fly   868 APTMSWPVAGTLMIEPTESEDKEELDRFCDAMISIREEIAEIEAGRMDKAVNPLKMSPHTQAQVI 932
            ||||||||||||||||||||||.|||||||||||||:|||:||.||:|..|||||||||:...|.
Mouse   897 APTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVT 961

  Fly   933 SDKWDRPYTREQAAFPAIFVKPDAKIWPTVGRIDDAYGDKHLVCTCPPI 981
            |..|||||:||.||||..||||:.|.|||:.||||.|||:||||||||:
Mouse   962 SSCWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPM 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3999	NP_001262456.1	PRK05367	35..981	CDD:235432	616/950 (65%)
		GDC-P	40..464	CDD:280502	255/427 (60%)
		GcvP2	494..949	CDD:223935	327/455 (72%)
Gldc	NP_613061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..51
		PRK05367	62..1014	CDD:235432	618/956 (65%)
		GDC-P	70..493	CDD:280502	255/428 (60%)
		GcvP2	509..982	CDD:223935	334/473 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845944
Domainoid	1	1.000	518	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_COG1003
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H141
Inparanoid	1	1.050	1276	1.000	Inparanoid score	I166
Isobase	1	0.950	-	0	Normalized mean entropy	S558
OMA	1	1.010	-	-		QHG62689
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002904
OrthoInspector	1	1.000	-	-		oto94509
orthoMCL	1	0.900	-	-		OOG6_101195
Panther	1	1.100	-	-	LDO	PTHR11773
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R482
SonicParanoid	1	1.000	-	-		X2723
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740