Protein Alignment CG42795 and GYL1

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_013917.1
• Gene: GYL1 / 855230
• SGDID: S000004804
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 772
• Identity: 158/772 - (20%)
• Similarity: 284/772 - (36%)
• Gaps: 195/772 - (25%)

  Fly  1288 NPKEDSHESEA-------ATNKKVEGNR-----ELSSEKGDHKI--KEKSEEAPGKAGKETAETK 1338
            |..||.||...       .|..:.:.:|     |:|..:||.|.  .||.|.|      .|..:.
Yeast     2 NSNEDIHEERIEVPRTPHQTQPEKDSDRIALRDEISVPEGDEKAYSDEKVEMA------TTNASS 60

  Fly  1339 NANVKDSSKKGD-----SQKNEAAKTSVSQTESDLK---PS---SKENSTSKDAEQEKTPR-KSP 1391
            |....:|:|.|:     |..:||...|..:.||..|   ||   |::..|.:...:|...| .||
Yeast    61 NFGSNESAKDGESIGAFSNPHEALMQSKLREESQSKTILPSDDLSQQLETEESKVEEALKRITSP 125

  Fly  1392 PSTEELEKRFNALEKQMSTTNLETTKEP-------DQTKPATKSQSTSAEVKTQKSMKSFDDKIK 1449
            |    |..|.:.:|:  |.:.|:::..|       ||. |..:.|....:|
Yeast   126 P----LPPRADCIEE--SASALKSSLPPVLAGNKNDQA-PLDRPQLPPRQV-------------- 169

  Fly  1450 EVNVAIEKEQSRVEVEVNAEKKRKNVEEAPKNKEGDSQQPEESQHKGKNQRRASEPP-STED--- 1510
                            ||||....   :||......|:.|..:.....:....:.|| ..||
Yeast   170 ----------------VNAETLHL---KAPHGNATPSKSPTSAVGNSSSSTPPTLPPRRIEDPLD 215

  Fly  1511 --LEKRY--ETLKRRM----SSKNQFSETVDEALERIQQEVISEAVEEKKPPPSTEDLESRFEAL 1567
              .:|.:  .|.||.|    |..|.....:|:.:..::::  |:.:...:.|   |::.|.:..:
Yeast   216 LAAQKHFLASTFKRNMLFYKSEDNSIKCDLDKNILNLKED--SKKINNNEIP---EEVSSFWLKV 275

  Fly  1568 HGDKKNVESKMDETKHVDVAIEAHIPSPPPPPPPPKERPVLAEPVLHQQQALIEEL-QSKMRGQS 1631
            .||.:|:.....||.|..::...          |...|.|:.:.|.:.:....:.: ::.:...:
Yeast   276 IGDYQNILINDIETLHFQLSRGI----------PAAYRLVVWQLVSYAKSKSFDPIYETYLTEMA 330

  Fly  1632 P-----GEENLKPSEINPQRRQKKL--LQRPTPMGDETSEAPANTAYY---------RAANHEQW 1680
            |     .|..||..:..|....|::  :.:...:.|...|...:.||.         ..||....
Yeast   331 PFDVQEFENQLKMMDEVPSEYVKRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGL 395

  Fly  1681 QQRMVR----RFSDLPSRADLENRLQFLERQLYKKFYKQ--RCASDSEVASRV------------ 1727
            ..|:::    |...|||.::::......:| |.::||.:  ....:..|.|.:
Yeast   396 LVRLMKVYGLRLLFLPSASEIDILCYKFDR-LVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQK 459

  Fly  1728 KLPPEDQPSTSRQARKQEAEGQLEQRVLA---------LEKQLSENSLKLLEA--MRERHRSADD 1781
            |||.|.||........:..:..:  |:||         |.|...::.|:||::  :....:..|.
Yeast   460 KLPTEIQPRIGDMVFLEGIDSIM--RILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDG 522

  Fly  1782 SGSPRRLSTETID-----------ATGKELVRYTQNIGELEEVDAHKPINISINIKMMVNKDSES 1835
            :.....||.|.:|           .|.|.:.:|:....|:..:|..|    .:..|.:..|:...
Yeast   523 TRGDTLLSNECMDKLLQDSMMKVAITPKTMKKYSSEYEEIHRLDNEK----EVQYKSITEKNLHL 583

  Fly  1836 KQPKGESKPTTEDLTRRLEQLEQQLLEERAKNGSIPPEN-----EVLEEKPEKLEEKDSCKKQEK 1895
            ::...:.:.....|.|....:..:|::.|....|:..||     ::|:.| :||   ||.||:
Yeast   584 QKHVRKLENDYTSLNREHVTIANELVKNRLNIESVLNENNGYKLQILDLK-KKL---DSEKKK-- 642

  Fly  1896 NCHNQHVKGDEVEKTEIPADRK--IEPASAKETKTLENVEKAQTRAKVVDTEKSVKD 1950
                      :|....:|.|.|  :|....|.|:.::...|.|.|  :.:.|:.:::
Yeast   643 ----------QVLGVYVPNDLKKDLEETMKKNTQVMDENLKLQDR--ISELERLIEE 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855
		DUF4682	560..689	CDD:464830
		PTZ00121	<1112..2009	CDD:173412	158/772 (20%)
		PTZ00121	<1740..2340	CDD:173412	47/240 (20%)
		PTZ00449	<2270..2610	CDD:185628
GYL1	NP_013917.1	COG5210	27..569	CDD:227535	123/605 (20%)