DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42795 and TBC1D17

DIOPT Version :10

Sequence 1:NP_001287272.1 Gene:CG42795 / 41252 FlyBaseID:FBgn0261928 Length:3213 Species:Drosophila melanogaster
Sequence 2:NP_078958.2 Gene:TBC1D17 / 79735 HGNCID:25699 Length:648 Species:Homo sapiens


Alignment Length:524 Identity:112/524 - (21%)
Similarity:178/524 - (33%) Gaps:176/524 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 VLIVESDDAQPKMRFS----------------LSPPPQKAITSARLTSPTKNSLSSNN----TIT 154
            ||:.::..:.|.:.|.                |:..||.  :...|..|..:|..||:    .:.
Human   142 VLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQD--SRLYLVFPHDSSALSNSFHHLQLF 204

  Fly   155 TPGSNN------RSPSSTKTTMLTR--NGGGHGTSPTASGSGHAPSATAAADDEATSDY------ 205
            ...|:|      :.|.||..:..:|  |.......|...|:  |.......|||....:      
Human   205 DQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGA--ASDLPPPPDDEPEPGFEVISCV 267

  Fly   206 ----------------NQWLHAMKLVARL-----------PGGTPPEFRRKLWLSL--------- 234
                            .:|...:....||           .||..|..||:.|..|         
Human   268 ELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGT 332

  Fly   235 -----------ADKY----LKSKNVDWAQQREKCFCEEWREDDEELGIQIVKDLHRTG--SNLCT 282
                       .|:|    |:.|:|...|:|.......:|.       .|.:|:.||.  :....
Human   333 AEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRS-------LIERDVSRTDRTNKFYE 390

  Fly   283 GP----AGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVL 343
            ||    .|.:|.     |||.|..|:.::||.||.:.|.:.||.|:..|.:.             
Human   391 GPENPGLGLLND-----ILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDA------------- 437

  Fly   344 PTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTN----------VFTM 398
                |:...|.::...|.|.|..:|...:|.:.|..|:     ..:|.|.:          .|..
Human   438 ----FWCFCGFMELVQGNFEESQETMKRQLGRLLLLLR-----VLDPLLCDFLDSQDSGSLCFCF 493

  Fly   399 QWFLTMFCTCLPMSCVLRVWDLVL--IEGSDVLLRTALVLWSLLE-ERVISVRSADEFYGKMGSY 460
            :|.|..|....|...|||:|:::.  :.|.::.|   ||..::|: ||...:.|        |..
Human   494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHL---LVACAILDMERDTLMLS--------GFG 547

  Fly   461 SSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHKQGL--QLYYDEEDTHSDEER 523
            |:|:|. |      :.|..:||. :||:             |...:.|  ||....|..|:.:|.
Human   548 SNEILK-H------INELTMKLS-VEDV-------------LTRAEALHRQLTACPELPHNVQEI 591

  Fly   524 LAVA 527
            |.:|
Human   592 LGLA 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42795NP_001287272.1 RabGAP-TBC 268..443 CDD:459855 47/193 (24%)
DUF4682 560..689 CDD:464830
PTZ00121 <1112..2009 CDD:173412
PTZ00121 <1740..2340 CDD:173412
PTZ00449 <2270..2610 CDD:185628
TBC1D17NP_078958.2 PH_RBD 7..205 CDD:432305 12/64 (19%)
Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040 218..309 14/92 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..259 6/20 (30%)
TBC 307..542 CDD:214540 64/271 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..648 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

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