DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42795 and TBC1D3

DIOPT Version :10

Sequence 1:NP_001287272.1 Gene:CG42795 / 41252 FlyBaseID:FBgn0261928 Length:3213 Species:Drosophila melanogaster
Sequence 2:NP_001116863.3 Gene:TBC1D3 / 729873 HGNCID:19031 Length:549 Species:Homo sapiens


Alignment Length:681 Identity:139/681 - (20%)
Similarity:216/681 - (31%) Gaps:260/681 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   204 DYNQWLHAMKLVARLPGGTPPEFRRKLW-LSLADKYLKSKNVDWAQ---QREKCFCEEWREDDEE 264
            |:.::..:.||:.|...|.|...|..:| :.|..:.:|.||....|   ::.|...|..:..|.:
Human    84 DWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRD 148

  Fly   265 LGIQIVKDL---HRTGSNLCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDK 326
            :...:.|.:   .|.|:          .|.:|..|||.|..||||||||:..:.:.||.|..:  
Human   149 VSGTLRKHIFFRDRYGT----------KQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYL-- 201

  Fly   327 EEEESMKVMIYL-------VEGV-LPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGP 383
            .||::...::.|       ::|. .|.|   |::.|||...   ..::.|..|:...|..:..  
Human   202 PEEDAFWALVQLLASERHSLQGFHSPNG---GTVQGLQDQQ---EHVVATSQPKTMGHQDKKD-- 258

  Fly   384 VENAFEPPLTNVFTMQWFLTMFC-TCLPMSCV-------------LRVWDLVLIEGSDVLLRTAL 434
                                 .| .|.|:.|:             ||:||:.|:||...|:....
Human   259 ---------------------LCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITR 302

  Fly   435 VLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNI 499
            :.:.:.::|:......    |....:.:..::....|.:.::                 |||   
Human   303 IAFKVQQKRLTKTSRC----GPWARFCNRFVDTWARDEDTVL-----------------KHL--- 343

  Fly   500 APLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLK 564
                              .:..::|.         .::|.:.|.|                    
Human   344 ------------------RASMKKLT---------RKKGDLPPPA-------------------- 361

  Fly   565 KQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGA 629
                                   ...|||   |:|:| ||.:     |......||.| .||.| 
Human   362 -----------------------KPEQGS---SASRP-VPAS-----RGGKTLCKGDR-QAPPG- 392

  Fly   630 IPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDTDPSRRRRDSLTWKEIKADRAAMIREGVDVSS 694
             ||||.|        :|            :| ...|.|..|.|....      ...:||  |...
Human   393 -PPARFP--------RP------------IW-SASPPRAPRSSTPCP------GGAVRE--DTYP 427

  Fly   695 VRTQKLRTRFGKSDSSSYSEDSDGEQESGTGGGGGS------------STDTSLCDDDDPKSTEK 747
            |.||.:       .|.:.::          ||..||            .||   .|.:.|.....
Human   428 VGTQGV-------PSPALAQ----------GGPQGSWRFLQWNSMPRLPTD---LDVEGPWFRHY 472

  Fly   748 SPKQKAKLARKLKEQKQLA--GSRETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGP 810
            ..:|.. ..|.:.::.|||  ...|...||.|....|||          |||     |:.|   |
Human   473 DFRQSC-WVRAISQEDQLAPCWQAEHPAERVRSAFAAPS----------TDS-----DQGT---P 518

  Fly   811 ITGDQAEDSATESGHYEFDRELHLVSSKMEP 841
            ......:..|..||.....  |||.||:..|
Human   519 FRARDEQQCAPTSGPCLCG--LHLESSQFPP 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42795NP_001287272.1 RabGAP-TBC 268..443 CDD:459855 45/199 (23%)
DUF4682 560..689 CDD:464830 27/128 (21%)
PTZ00121 <1112..2009 CDD:173412
PTZ00121 <1740..2340 CDD:173412
PTZ00449 <2270..2610 CDD:185628
TBC1D3NP_001116863.3 TBC 99..312 CDD:214540 57/253 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..419 30/159 (19%)
PHA03381 <356..>468 CDD:177618 42/215 (20%)
Blue background indicates that the domain is not in the aligned region.

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