Protein Alignment CG42795 and TBC1D14

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_011511809.1
• Gene: TBC1D14 / 57533
• HGNCID: 29246
• Length: 727
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 68/286 - (23%)
• Similarity: 108/286 - (37%)
• Gaps: 88/286 - (30%)

  Fly   221 GTPPEFRRKLWLSLA---DKYLKSKNVDWAQQREKCFCEEWR-----------ED------DEEL 265
            |.||..|.|:| |||   :..:..:..|....|.|   |.||           ||      |.|.
Human   401 GIPPSVRGKVW-SLAIGNELNITHELFDICLARAK---ERWRSLSTGGSEVENEDAGFSAADREA 461

  Fly   266 GIQIVK-DLHRTGSNLC------------TGPAGSINQAK----------------------LKR 295
            .::::| |:.||..|||            .|...|..:.|                      |..
Human   462 SLELIKLDISRTFPNLCIFQQVLIFVDFRVGLQKSFQKRKERESTKLQQLWSWCLGGPYHDMLHS 526

  Fly   296 ILLGYARYNPEVGYCQGFNMLGALILQVMDKEE---------EESMKVMIYLVEGVLPTGYFYGS 351
            ||..|..|.|:|||.||.:.:.|:::..:|..:         .:..::..:.|:..|...||
Human   527 ILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYF--- 588

  Fly   352 MGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLR 416
                    ..|....:..||:|..|.::      |...|   :::.:.|..|::...||:....|
Human   589 --------AAFEVFFEENLPKLFAHFKK------NNLTP---DIYLIDWIFTLYSKSLPLDLACR 636

  Fly   417 VWDLVLIEGSDVLLRTALVLWSLLEE 442
            :||:...:|.:.|.||||.:..|.|:
Human   637 IWDVFCRDGEEFLFRTALGILKLFED 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	49/219 (22%)
		DUF4682	560..689	CDD:464830
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
TBC1D14	XP_011511809.1	ERM_helical	329..>368	CDD:466641
		TBC	398..664	CDD:214540	68/286 (24%)