DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42795 and TBC1D2

DIOPT Version :10

Sequence 1:NP_001287272.1 Gene:CG42795 / 41252 FlyBaseID:FBgn0261928 Length:3213 Species:Drosophila melanogaster
Sequence 2:NP_001254500.1 Gene:TBC1D2 / 55357 HGNCID:18026 Length:928 Species:Homo sapiens


Alignment Length:607 Identity:149/607 - (24%)
Similarity:244/607 - (40%) Gaps:134/607 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSETKKLLDALLCDIYGRQEVLAKRIRRCCRDPVH--KRSPKK----------KKGQLAQLASGM 53
            :.|.::.:..|:...:.:|:|:.|...:..:|..|  .:||.:          ::|::..|...|
Human   397 VQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDM 461

  Fly    54 VGDRS-----SLERLDVRK-----------LIDVCAIL-----KVEILMLGYLLERVLVARDRLQ 97
            ...|:     :.|...|.|           |:..||.|     :||...|..|........|...
Human   462 EAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEAS 526

  Fly    98 RHQEVLCEFVTAVLIVESDDAQPKMRFSLSP-----------PPQKAITSARLTSPTKNSLSSNN 151
            ...|:|.:.|...|..|:.:|... ...|||           .|...:...:|.:..:...|.::
Human   527 ECSELLRQLVQEALQWEAGEASSD-SIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSH 590

  Fly   152 TITTPGSNNRSPSSTKTTMLTRNGGGHGTSPTASGSGHAPSATAAADDEATSDYNQWLHAMKLVA 216
            .:....:.:| |...:...|               ....|||          :..|.|.|     
Human   591 HLLGLEAVDR-PLRERWAAL---------------GDLVPSA----------ELKQLLRA----- 624

  Fly   217 RLPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCFCE---EWREDDEELGIQIVKDLHRTGS 278
                |.|.|.|.::|..|.  :|:.:::    ....|:.|   ..:..:.....||..||:||..
Human   625 ----GVPREHRPRVWRWLV--HLRVQHL----HTPGCYQELLSRGQAREHPAARQIELDLNRTFP 679

  Fly   279 N--LCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEG 341
            |  ..|.|..|... ||:|:||.::..||.:|||||.|.|.|:.|.|:: |||.:...::.:||.
Human   680 NNKHFTCPTSSFPD-KLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLE-EEESAFWCLVAIVET 742

  Fly   342 VLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFC 406
            ::|..|:..::...|.|..|.::|:..:||||..||.  |..|:       .::.|..|||.:|.
Human   743 IMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLG--QHHVD-------LSLVTFNWFLVVFA 798

  Fly   407 TCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADE------FYGKMGSYSSELL 465
            ..|..:.:|||||..|.||:.|:.|.||.::...|:.::.:::..|      |:.|..|.|.:|:
Human   799 DSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLM 863

  Fly   466 NGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNI-APLRHKQGLQLYYDEEDTHSDEERLAVATV 529
            |....|.|..        .::.|||||..|...: |.||..:.|:..|        .||.|    
Human   864 NIAFNDMNPF--------RMKQLRQLRMVHRERLEAELRELEQLKAEY--------LERRA---- 908

  Fly   530 FGLNWGRRGSVGPAAAGKQQVE 551
                 .||.:|....|.:.:||
Human   909 -----SRRRAVSEGCASEDEVE 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42795NP_001287272.1 RabGAP-TBC 268..443 CDD:459855 65/176 (37%)
DUF4682 560..689 CDD:464830
PTZ00121 <1112..2009 CDD:173412
PTZ00121 <1740..2340 CDD:173412
PTZ00449 <2270..2610 CDD:185628
TBC1D2NP_001254500.1 SMC_prok_B <276..480 CDD:274008 15/82 (18%)
Interaction with RAC1. /evidence=ECO:0000269|PubMed:20116244 295..433 7/35 (20%)
TBC 625..837 CDD:214540 74/228 (32%)
Interaction with CADH1 1..169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
PH_TBC1D2A 47..147 CDD:269966
Atrophin-1 <183..>292 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..275
Blue background indicates that the domain is not in the aligned region.

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