Protein Alignment CG42795 and Tbc1d8

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_017177250.1
• Gene: Tbc1d8 / 54610
• MGIID: 1927225
• Length: 1160
• Species: Mus musculus
• Alignment Length: 674
• Identity: 153/674 - (22%)
• Similarity: 256/674 - (37%)
• Gaps: 193/674 - (28%)

  Fly   213 KLVARLPGGTPPEFRRKLWLSLADKY--LKSKNVDWAQQREK-----CFCEEWREDDEELGIQIV 270
            ||||.   |.|...|.:|||..:|..  |.|....:....|:     |...|          :|.
Mouse   514 KLVAM---GIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEQSLGRCCLVTE----------EIE 565

  Fly   271 KDLHRTGSNLCTGPA--GSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMK 333
            :||||   :|...||  .....|.|:|:|..||..||::||||..|:|.:::|  :..:|||:..
Mouse   566 RDLHR---SLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLL--LYAKEEEAFW 625

  Fly   334 VMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTM 398
            :::.:.|.:|| .||...:.|.|.|..||.||::.:||.||:|:..|..         |.:: ::
Mouse   626 LLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKEQLPELAEHMSDLSA---------LASI-SL 679

  Fly   399 QWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVIS----------------- 446
            .||||:|.:.:|:...:.|.|....:|...:.:..|.:.....|.:.|
Mouse   680 SWFLTLFLSIMPLESAVHVVDCFFYDGIKAIFQLGLAVLEANAEELCSSKDDGQALMVLSRFLDH 744

  Fly   447 ---------------------------------VRSADEFY--------GKMGSYSSE------- 463
                                             :|.:.|.:        .|.|:.|.|
Mouse   745 IKNEDSPGPPIGSHHAFFSDDQEPYPVTDIADLIRDSYELWTQAVPVSMQKFGNQSVEQIEHLRC 809

  Fly   464 -----LLNGHLVDSNGLIERV----VKLGPIEDLRQLRDKHLYNIAPL-----RHKQGLQLYYDE 514
                 :|.||...:...:.||    |.:.| |||.:|.|  |:..|.:     .|.:.:.|.:|.
Mouse   810 KHRIRVLQGHEDTTKQNVLRVVIPEVSILP-EDLEELYD--LFKRAHMMSCYWEHHRPMALRHDP 871

  Fly   515 EDTHSDEERL---AVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQKQ 576
            ...::::.|:   ..|.:|.|       |.|...|.......:||   ..||....|:|.|.:
Mouse   872 SRPYAEQYRIDARQFAHLFQL-------VSPWTCGVHTEILAERL---FRLLDDNMDQLIEFK-- 924

  Fly   577 AHVILTTACSTAARQGSGPASSSQPAVPVNQLL-----LGRPAIVTNKGKRVGAPLGAIPPARKP 636
                ..|:|......|.           :|:.:     |..|..:|...:...:||.  .|....
Mouse   925 ----AFTSCLDIMYNGE-----------MNEKIKLLYRLHIPPALTENDRDSQSPLK--NPLLST 972

  Fly   637 SLPAVLHTKPTSEKQLRRGETLLWRDTDPSRRRRDSLTWKEIKADRAAMIREGVDVSSVRTQKLR 701
            |.|.|| .||       .|:|:     |..::.:..:  |::..::..|.:|...:|    |:..
Mouse   973 SRPLVL-GKP-------NGDTI-----DYQKQLKQMI--KDLAKEKDKMEKELPKMS----QREF 1018

  Fly   702 TRFGKSDSSSYSEDSDGEQ-------------ESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKA 753
            .:|.|:..|.:.||.:...             :.|..|..|||:.:...:.::|::: ..|:|.:
Mouse  1019 IQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQRGSSSGSCSQECEEPQAS-APPEQDS 1082

  Fly   754 KLARKLKEQK---QLAGSRETSLE 774
            ..|...|..:   :..|....|||
Mouse  1083 VFAEAGKSPQAFPETEGDWTVSLE 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	55/176 (31%)
		DUF4682	560..689	CDD:464830	26/133 (20%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
Tbc1d8	XP_017177250.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	519..725	CDD:214540	68/231 (29%)