Protein Alignment CG42795 and plx

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Alignment Length: 852
• Identity: 169/852 - (19%)
• Similarity: 294/852 - (34%)
• Gaps: 278/852 - (32%)

  Fly   210 HAMKLVARLPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCF----------CEEWREDDEE 264
            ||::.      |.|...|..:|..||:::    :::.|....|.|          .:...|....
  Fly   931 HAIRT------GVPRSKRGDVWTFLAEQH----SMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHA 985

  Fly   265 LGIQIVKDLHRTGSN--LCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNML-GALILQVMDK 326
            :.|    ||.||..|  ....|.| :.|..|..:|..|:..:||:|||||...: |.|:|..
  Fly   986 IFI----DLGRTFPNHQFYKDPLG-LGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHC--- 1042

  Fly   327 EEEESMKVMIYLV-EGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAK-HLQRLQGPV-ENAF 388
            :|..|.:::.:|: ...:.|.|.        .||..| :|...:|.||.| ||..|...: :|..
  Fly  1043 DEANSFQLLKHLMFRRNMRTKYL--------PDMKKF-QLQLYQLSRLVKDHLPDLYVWLDQNDV 1098

  Fly   389 EPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEF 453
            .|.|   :...|.||:|.:..|:..|.||:||:.:|.|||:.:.|:.|.|:.::::::..:.:|.
  Fly  1099 SPTL---YAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEI 1160

  Fly   454 YGKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYDEEDTH 518
            ...:.:...::       .:..:|:::||
  Fly  1161 MDYLKTVVPKM-------EHTCMEQIMKL------------------------------------ 1182

  Fly   519 SDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQK---DRLALDISLLKKQYDRL-RERQKQAHV 579
                      ||.::           .|||..|.|   :.|..:|:......:.| ||:.:..|:
  Fly  1183 ----------VFSMD-----------IGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHL 1226

  Fly   580 --ILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVL 642
              .|..|.|:.|:..:..:|.......:...:......:...|:.||..:...|....|:
  Fly  1227 EQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPN----- 1286

  Fly   643 HTKPTSEKQLRRGETLLWRDTDPSRRRRDSLTWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKS 707
                    ::||   :|.:..|..|:||     |.|..:|  .|.:.|.|:|.....|:..
  Fly  1287 --------EVRR---MLQQLDDLDRQRR-----KPIFTER--KIGKSVSVNSHLGFPLKVL---- 1329

  Fly   708 DSSSYSEDSDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQ---LAGSR 769
                                      ..|.:.|:..|.:|..|:|.....:|::|:|   |.|..
  Fly  1330 --------------------------EELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGG 1368

  Fly   770 ETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGDQAEDSATESGHYEFDRELHL 834
            ::|   ...:|.:|:....|..|:  |:...:.....|...:...:..|.              .
  Fly  1369 QSS---NVGESGSPTPPSRPNRLL--DNASARTVMQVKLDELKLPEHVDK--------------F 1414

  Fly   835 VSSKMEPLKL------PFDPEFT-------------GMTSVSPIPTPREKSEAEEDLLDERKPFD 880
            |::...||::      |..|..|             |..:..|..:|          |.:|:.:.
  Fly  1415 VANIKSPLEVDSGVGTPLSPPSTASNSSGGSIFSRMGYRTTPPALSP----------LAQRQSYG 1469

  Fly   881 VSDDGVTN----QYFERV-----------NSVERPNRLELTYSLNEEETDTNAIYLEEREKVEGH 930
            |:   :|.    |:.|.|           ..||.|..:   :.|:....|.|..:
  Fly  1470 VA---ITTAPCPQHMEEVAPATTMAVMPQEDVEEPQPM---HPLSMVGGDVNVRF---------- 1518

  Fly   931 SGDREYNSLPPFY-----PRENDDGVQGGGKV-PQIRDDNIPGENKDDYKELLSMTIEENTVYKP 989
            .|..:..|:.|.:     |.   .|||..... |.:|...:|.|                  ..|
  Fly  1519 KGTTQLKSIRPVHHMRAIPL---GGVQHPSSTEPAVRVAPVPVE------------------LAP 1562

  Fly   990 PTPTAST 996
            |..||:|
  Fly  1563 PAATATT 1569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	57/180 (32%)
		DUF4682	560..689	CDD:464830	26/131 (20%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365
		TBC	933..1152	CDD:214540	68/248 (27%)
		COG4372	<1190..>1353	CDD:443500	41/215 (19%)