Protein Alignment CG42795 and Tbc1d2

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_006538109.1
• Gene: Tbc1d2 / 381605
• MGIID: 2652885
• Length: 923
• Species: Mus musculus
• Alignment Length: 599
• Identity: 140/599 - (23%)
• Similarity: 225/599 - (37%)
• Gaps: 177/599 - (29%)

  Fly    16 YGRQEVLAKRIRRCCRDPVHKRSPKKKKGQLAQLASGMVGD-RSSLERLDVRK------------ 67
            :.:|:|:.|..::...|             |||.|....|| .|..||::..|
Mouse   416 HAKQQVICKLTQKLTED-------------LAQPADATNGDFLSQQERMEHLKDDMEAYRTQNRF 467

  Fly    68 ---------------------LIDVCAILKVEILMLGYLLERVLVARDRLQR--------HQEVL 103
                                 |:..||.|:.....:.   .:.|....|||.        ..|:|
Mouse   468 LNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVE---SKYLAGLRRLQEAAGAEAGDFPELL 529

  Fly   104 CEFVTAVLIVESDDAQPKMRFSLSPPPQ-----------------KAITSARLTSPTKNSLSSNN 151
            .:.:...|..|:.:|.   ...|||..:                 |.:...:......:.|.::.
Mouse   530 QQLIQEALQWEAGEAD---SVGLSPVSEYDDYGFLTVPDYEMEDLKLLAKIQALEVRSHHLLAHE 591

  Fly   152 TITTPGSNNRSPSSTKTTMLTRNGGGHGTSPTASGSGHAPSATAAADDEATSDYNQWLHAMKLVA 216
            .:..| ..:|..:.|:.|                     |||          :..|.|.|
Mouse   592 AVERP-LRDRWATLTELT---------------------PSA----------ELKQLLRA----- 619

  Fly   217 RLPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCFCE---EWREDDEELGIQIVKDLHRT-- 276
                |.|.|.|.::|..|..:.::.      .|...|:.|   ..|..:.....||..||:||
Mouse   620 ----GVPREHRPRVWRWLVHRRVRH------LQAPGCYQELLARGRACEHPAARQIELDLNRTFP 674

  Fly   277 GSNLCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEG 341
            .:...|.|..|... ||:|:||.::..||.:|||||.|.|.|:.|.|:: :||.:...::.:||.
Mouse   675 TNKHFTCPTSSFPD-KLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLE-DEESAFWCLVAIVET 737

  Fly   342 VLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFC 406
            :||..|:..::...|.|..|.::|:..:||||..||.  |..|:       .::.|..|||.:|.
Mouse   738 ILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLG--QHRVD-------LSLITFNWFLVVFA 793

  Fly   407 TCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGKMGSY------SSELL 465
            ..|....:|||||..|.||:.|:.|.||.::...||.::.::.:.|.|..:..:      |.:|:
Mouse   794 DSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTKTICDSRKLM 858

  Fly   466 NGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNI-APLRHKQGLQLYYDEEDTHSDEERLAVATV 529
            :....|.|..        |::.|||||..|...: |.||..:.|::.|.:
Mouse   859 SIAFNDMNPF--------PMKQLRQLRAAHRERLEAELRELELLKVEYLQ--------------- 900

  Fly   530 FGLNWGRRGSVGPA 543
                  ||.|:|.|
Mouse   901 ------RRASLGRA 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	64/176 (36%)
		DUF4682	560..689	CDD:464830
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK12323	<192..404	CDD:481241
		COG4913	<307..>464	CDD:443941	14/60 (23%)
		TBC	620..832	CDD:214540	75/228 (33%)